摘要
目的:探讨早期血液滤过(HF)对重症急性胰腺炎(SAP)合并急性肾损伤(AKI)患者的预后影响。方法:选取某院2014年6月~2017年2月接收的SAP合并AKI患者98例,随机分为两组,各49例。对照组采取常规治疗,观察组在此基础上采取早期HF治疗,记录比较两组治疗后血清白细胞介素IL-6、IL-1β、肿瘤坏死因子-α(TNF-α)水平及治疗前后血清尿素氮、肌酐水平的变化。结果:观察组治疗后血清IL-6、IL-1β及TNF-α水平与对照组相比均明显降低(P<0.05);两组治疗前血清尿素氮、肌酐含量无明显差异(P>0.05),治疗后均显著降低(P<0.01),且观察组下降更显著(P<0.01)。结论:早期HF治疗可有效降低SAP合并AKI患者机体炎症因子水平、保护肾功能、提高患者救治率、改善预后,值得临床推广。
Objective：To investigate the prognostic effect of early hemofiltration （HF） in patients with severe acute pancreatitis （SAP）complicated with acute kidney injury（AKI）.Methods：98 patients with SAP combined with AKI treated in a hospital from June 2014 to February 2017 were selected and randomly divided into twogr oups,with 49 cases in each group.The patients in the control group were given routine treatment while patients in the observation group were given early HF treatment based on the treatment in the control group.The changes of serum levels of interleukin （IL）-6,IL-1β,tumor necrosis factor-α（TNF-α）after treatment,and serum levels of ureanitrogen and creatinine before and after treatment in the two groups were recorded and compared.Results：The serum levels of IL-6,IL-1β and TNF-α in the observation group were significantly lower than those in the control group after the treatment（P〈0.05）.There was no significant difference in serum ureanitrogen and creatinine content between the two groups before the treatment（P〉0.05）.After thetreatment,all indexes were decreased significantly（P〈0.01）,and they were decreased more significantly in the observation group（P〈0.01）.Conclusion：The early HF tratment can effectively reduce the levels of inflammatory factors in SAP patients with AKI,protect renal function,improve the rate of treatment and improve prognosis,which is worthy of clinical promotion.
作者
丘伟杰
池伟文
Qiu Weijie(Department of Critical Medicine,Yuedong hospital,No.3 Hospital Affiliated to Sun Yat-Sen University,Meizhou 514700)
出处
《数理医药学杂志》
2018年第9期1287-1289,共3页
Journal of Mathematical Medicine
