摘要
目的:探讨头孢西丁钠头孢克肟序贯治疗慢阻肺急性加重期的临床效果。方法:将2016年1月~2017年1月80例慢阻肺急性加重期患者作为对象根据随机信封法分组,各有40例。静滴治疗组采用头孢西丁钠静脉滴注治疗,序贯治疗组采用头孢西丁钠头孢克肟序贯治疗,比较两组慢阻肺急性加重期治疗效果、症状消失时间、治疗天数、人均治疗总费用、抗菌药费用、干预前后患者肿瘤坏死因子-α、C反应蛋白。结果 :序贯治疗组慢阻肺急性加重期治疗效果高于静滴治疗组,P<0.05;序贯治疗组症状消失时间、治疗天数、人均治疗总费用、抗菌药费用少于静滴治疗组,P<0.05;干预前两组肿瘤坏死因子-α、C反应蛋白相近,P>0.05;干预后序贯治疗组肿瘤坏死因子-α、C反应蛋白优于静滴治疗组,P<0.05。结论 :头孢西丁钠头孢克肟序贯治疗慢阻肺急性加重期的临床效果确切,优于头孢西丁钠静滴治疗,可更好控制机体炎症,缩短疗程,加速症状消退,减少抗菌药物和治疗费用,值得推广。
Objective：To investigate the clinical effect of sequential cefoxitin sodium and cefoxime in the treatment of acute exacerbation of chronic lung disease.Methods：80 patients with acute exacerbation of chronic lung disease treated in a hospital from January 2016 to January 2017 were selected and divided into intravenous drip group and sequential therapy group according to the random envelope method,with 40cases in each group.The intravenous drip group was treated with cefoxitin sodium intravenous injection and the sequential therapy group was treated with cefoxitin sodium and cefoxime.The effect of treatment in acute exacerbation of COPD,the time of symptom disappearance,the days of treatment,the total cost of treatment per capita,the cost of antimicrobial agents and the tumor necrosis factor-α,and the C reactive protein before and after intervention were compared between the two groups.Results：The effect of sequential therapy group was higher than that of intravenous drip group in acute exacerbation of COPD （P〈0.05）.The time of disappearance of symptoms,the days of treatment,the total cost of treatment per capita,and the cost of antibiotics in sequential therapy group were less than those in intravenous drip group （P〈0.05）.Before intervention,the TNF-alpha and C reactive protein were similar in the two groups（P〉0.05）;After intervention,the umor necrosis factor-αand c-reactive protein in the sequential therapy group were superior to the intravenous drip group（P〈0.05）.Conclusion：The sequential treatment of cefoxitin sodium and cefoxime is more effective than sodium intravenous drip in the treatment of acute exacerbation of chronic obstructive pulmonary disease,which can better control inflammation,shorten the course of treatment,accelerate the remission of symptoms,and reduce the antimicrobial agents and the cost of treatment,and is worthy of promotion.
作者
郝菁菁
Hao Jingjing(Department of Respiratory Medicine,Luoyang No.1 People＇s Hospital,Luoyang 471000)
出处
《数理医药学杂志》
2018年第9期1341-1343,共3页
Journal of Mathematical Medicine
关键词
头孢西丁钠
头孢克肟
序贯治疗
慢阻肺急性加重期
临床效果
cefoxitin sodium
cefoxime
sequential therapy
acute exacerbation of chronic lung disease
clinical effect
