摘要
目的探讨前列腺液锌(Zn)水平在不同类型慢性前列腺炎患者诊断中的临床价值。方法选取慢性细菌性前列腺炎(CBP)患者(BP组)36例、慢性非细菌性前列腺炎(NCBP)患者(NCBP组)36例,以40名男性体检健康者作为正常对照组。检测所有对象前列腺液Zn和C反应蛋白(CRP)水平,同时进行外周血白细胞(WBC)计数。采用受试者工作特征(ROC)曲线评价前列腺液Zn水平鉴别诊断CBP的价值。采用Pearson相关分析评价前列腺液Zn水平与前列腺液CRP水平、外周血WBC计数的相关性。结果 CBP组、NCBP组、正常对照组前列腺液Zn水平依次升高,各组间差异均有统计学意义(P<0.05)。CBP组前列腺液CRP水平及外周血WBC计数、中性粒细胞绝对数(NEUT#)均明显高于NCBP组和正常对照组(P<0.05),而NCBP组与正常对照组之间差异无统计学意义(P>0.05)。ROC曲线分析显示,前列腺液Zn水平鉴别诊断CBP的曲线下面积为0.845,最佳临界值为502.6 mg/L,敏感性为83.5%,特异性为79.3%。前列腺液Zn水平与前列腺液CRP水平及外周血WBC计数均呈负相关(r值分别为-0.521、-0.125,P<0.05)。结论前列腺液Zn水平可辅助诊断慢性前列腺炎,结合前列腺液CRP水平及外周血WBC计数可辅助鉴别不同类型的慢性前列腺炎。
Objective To investigate the role of zinc（Zn） level in prostatic fluid for the diagnosis of different types of chronic prostatitis.Methods A total of 36 patients with chronic bacterial prostatitis（CBP） and 36 patients with non-chronic bacterial prostatitis（NCBP） were enrolled,and 40 healthy males were enrolled as healthy control group. Zn and C-reactive protein（CRP） levels were determined. Peripheral blood white blood cell（WBC） count was determined as well. The role of Zn level in prostatic fluid for the diagnosis of CBP was evaluated by receiver operating characteristic（ROC） curve. The correlations of Zn level in prostatic fluid with CRP level and WBC count were evaluated by Pearson correlation analysis.Results The levels of Zn in prostatic fluid in CBP,NCBP and healthy control groups were increased in turn（P〈0.05）. The CRP level,WBC count and neutrophil absolute value（NEUT#） in CBP group were higher than those in NCBP and healthy control groups（P〈0.05）. There was no statistical significance between NCBP group and healthy control group（P〉0.05）. ROC curve analysis showed that the area under the curve of Zn level in prostatic fluid for the diagnosis of CBP was 0.845,the optimal cut-off value was 502.6 mg/L,the sensitivity was 83.5%,and the specificity was 79.3%. The Zn level in prostatic fluid was negatively correlated with CRP level and WBC count（r=-0.521 and -0.125,P〈0.05）.Conclusions Zn level in prostatic fluid can help with diagnosing chronic prostatitis. Combined with CRP level and WBC count,it can assist to distinguish different types of chronic prostatitis.
作者
张斌
周晓磊
ZHANG Bin;ZHOU Xiaolei(Department of Clinical Laboratory,Jinshan Hospital,Fudan University,Shanghai 201508,China)
出处
《检验医学》
CAS
2018年第8期683-685,共3页
Laboratory Medicine
关键词
锌
前列腺液
慢性前列腺炎
Zinc
Prostatic fluid
Chronic prostatitis
