摘要
目的 :建立大鼠睾丸纤维化模型 ,为进一步研究睾丸纤维化的发病机制打下良好基础。 方法 :将Wistar大鼠分为正常组 (12只 )和模型组 (40只 ) ,采用制造自身免疫性睾丸炎的经典方法结合单侧睾丸内注射卡介苗 ,建立睾丸纤维化模型。 结果 :距第 1次免疫 80d时 ,自身免疫性睾丸炎的发生率为 10 0 % ,睾丸纤维化的发生率为11.1% ;距第 1次免疫 14 0d时 ,自身免疫性睾丸炎的发生率为 10 0 % ,睾丸纤维化的发生率为 81.5 %。 结论
Objectives: To establish the testicular fibrosis model in rats. Methods: Wistar rats were divided into control group( n =12) and model group( n =40) randomly. Testicular fibrosis model was built with the classical method of establishing experimental autoimmune orchitis (EAO) combined with injecting Bacille Calmette Guerin (BCG) into left testis. Results: The incidence rate of EAO and the rate of testicular fibrosis were 100%, 11.1% and 100%,81.5% at 80, 140 days after the first infection, respectively. Conclusions: The model of rat testicular fibrosis was established successfully.
出处
《中华男科学杂志》
CAS
CSCD
2002年第4期266-269,共4页
National Journal of Andrology
