摘要
目的系统评价脑梗死患者颈动脉粥样硬化斑块与血清甲壳质酶蛋白40(chitin enzymes protein40,YKL-40)的关系。方法在CNKI、万方医学、PubMed数据库检索已发表的关于血清YKL-40对动脉粥样硬化性脑梗死(atherosclerotic cerebral infarction,ACI)影响的相关文献,截止日期为2018年1月1日。筛选出ACI患者(ACI组)与非ACI患者(对照组)血清YKL-40水平的病例-对照研究,对纳入的文献进行质量评价和资料提取,采用RevMan 5.3进行meta分析。结果共纳入7篇病例对照研究,包括ACI组649例,对照组290例。结果显示:ACI组血清YKL-40水平显著高于对照组,差异有统计学意义(SMD=1.55,95%CI=1.39~1.71,P<0.01);而ACI组斑块稳定的患者YKL-40水平显著低于斑块不稳定的患者,差异有统计学意义(SMD=-1.60,95%CI=-1.84^-1.35,P<0.01)。结论血清YKL-40水平与我国ACI的发生呈正相关,且血清YKL-40越高,动脉粥样硬化斑块的稳定性越差。
Objective To systematically evaluate the relationship between the carotid atherosclerotic plaque and the serum chitin enzymes protein 40 （YKL 40） level in patients with atherosclerotic cerebral infarction （ACI）. Methods Literature about the influence of serum YKL 40 levelonACIpublished before Jan.1, 2018 were searched. The search was conducted in databases including CNKI, Wanfang Dataand PubMed. The casecontrol study about the YKL40 levelbetween ACI patients（ACI group） and patients without ACI（control group） were included in this study. Quality evaluation and data extraction were carried out, and meta analysis was performed by RevMan 5.3.Results Sevencasecontrol studies were included in this study, including 649 patients in the ACI group and 290patientsin the control group. The result showed that the serum YKL 40 level of the ACI group were much more higher than that of thecontrol group, and the differences is statistically significant （SMD=1.55,95%CI=1.391.71,P〈0.01）; In the ACI group, the serum YKL 40 level among patientswith stable plaques was lower than that of patients withunstable plaques. Conclusion The level of serum YKL40 is positively correlated with the occurrence of ACI in China, and the higher the serum YKL40 is, the worse the stability of atherosclerotic plaques is.
作者
严雯
孙波
任建功
Yan Wen;Sun Bo;Ren Jiangong(Departrment of Neurology,the First People＇s Hospital of Lanzhou,Lanzhou 730050,China)
出处
《临床荟萃》
CAS
2018年第8期700-704,共5页
Clinical Focus
