摘要
藤黄Ⅱ号是从传统中药藤黄中提取的新的抗肿瘤有效成分,药理实验表明:本品对小鼠白血病L1210的抑制作用优于藤黄酸,对艾氏腹水癌,P388,ARS腹水及Lewis肺癌等实体瘤亦有明显抑制作用,和马蔺子甲素及放射合用,可明显增加对小鼠宫项癌U14的疗效。腹腔注射及口服藤黄Ⅱ号,对La795肺腺癌的肺转移亦有明显抑制作用。
Gambegic H is a new effective anticancer principle extracted from traditional Chinese medicine Gamboge (garcinia hanburryi) The pharmacological studies showed that Gambegic II was more effective against L1210 in mice than Gambogic acid. It also exhibited significant inhibiting activity against Ehrlich ascites carcinoma, p388 leukemia, ARS ascites carcinoma, Lewis lung carcinoma and some other solid tumors in mice. Gambogic II was effective in treating U14 cervix carcinoma of mouse when it was combined with irradiation or Iq 7611, a kind of radiosensitizer from Chinese herbal drug. The antimetastatic effect of Gambogic II was also exampli-fied by showing a significant inhibiting action on spontaneous pulmonary metastasis in mice bearing La795 carcinoma.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1991年第1期50-52,共3页
Chinese Journal of Clinical Oncology
基金
天津市科委重点资助
关键词
藤黄Ⅱ号
抗癌作用
实验研究
Traditional Chinese medicine Gambogic II Antineoplastic action Experimental studies
