摘要
目的探讨结肠腺瘤性息肉中p53、Ki-67和CD34表达及其与病变程度的关系。方法用免疫组化法检测38例低危和24例高危性结肠腺瘤性息肉中p53、Ki-67和CD34表达,并分析其与病理指标的关系。结果高危组中p53、Ki-67、CD34表达均明显高于低危组(P<0.01或0.05)。p53、Ki-67、CD34表达与息肉大小、个数、不典型增生及病理分型有关(P<0.01或0.05)。结论 p53、Ki-67、CD34检测有助于分析结肠腺瘤性息肉的病变程度。
Objective To study the relationship between expression of p53, Ki-67 and CD34 and degree of lesion in colon adenomatous polyps. Methods The expression of p53, Ki-67 and CD34 was determined by immunohistochemistry in 38 low and 24 high risk cases of colon adenomatous polyps and their relation to pathological indexes was analyzed. Results Expression of p53, Ki-67 and CD34 was increased in high risk group compared with low risk group（P〈0.01 or 0.05）. Their expression was correlated with lesional size and number, atypical hyperplasia, and pathological classification（P〈0.01 or 0.05）. Conclusion The detection of p53, Ki-67 and CD34 is helpful to determine the lesional degree of colon adenomatous polyps.
作者
江康伟
陈焕伟
杨利敏
JIANG Kang-wei;CHEN Huan-wei;YANG Li-min(Guangdong Agricultural Reclamation Center Hospital,Zhanjiang Tumor Hospital,Zhanjiang 524002,China)
出处
《广东医科大学学报》
2018年第1期67-69,共3页
Journal of Guangdong Medical University
