摘要
目的探讨抗精神病药物单一与联合用药对首次复发精神分裂症患者持续用药时间的影响及停药原因。方法 219例首次复发精神分裂症患者根据患者的用药情况分为单一组和联合组。单一组89例,接受第一代抗精神病药物(FGA)或第二代抗精神病药物(SGA)治疗;联合组130例,接受FGA+FGA或FGA+SGA或SGA+SGA治疗。比较两组的持续用药时间、停药原因与用药期间的药物不良反应。结果单一组患者持续用药时间较联合组短[(39.23±12.37)周vs(52.81±20.53)周,P<0.01],因药物不良反应原因停药者多于联合组(P<0.05),药物不良反应的发生率较联合组高(P<0.05)。结论抗精神病药物单一用药患者的持续用药时间比联合用药者短,药物不良反应较多且为主要停药原因。
Objective To explore the effect of single medication and drug combination on the duration of medication in patients with first recurrent schizophrenia and the causes for drug withdrawal. Methods 219 patients with first relapse of schizophrenia were divided into Single Group and Combination Group according to their medication. 89 cases in Single Group were administered with first-generation antipsychotics（FGA） or second-generation antipsychotic drugs（SGA） while 130 cases in Combination Group were administered with FGA＋FGA, FGA＋SGA or SGA＋SGA. The duration of medication, reasons fordrug withdrawal and adverse drug reactions during the medication were compared between the two groups. Results Single Group had the duration of medication shorter than Combination Group [（39.23±12.37） weeks vs（52.81±20.53） weeks, P〈0.01]. More patients in Single Group withdrew the drugs due to adverse drug reactions than Combination Group（P〈0.05）. Single Group had a higher incidence of adverse drug reactions than Combination Group（P〈0.05）. Conclusion The patients that have received single medication of antipsychotics have a shorter duration of medication and more adverse drug reactions than those that have received drug combination. Adverse drug reaction is the main reason for drug withdrawal.
作者
陈健
潘志清
蔡方校
万诚
许锦泉
陈泽元
CHEN Jian;PAN Zhi-qing;CAI Fang-xiao;WAN Cheng;XU Jin-quan;CHEN Ze-yuan(The Third People＇s Hospital of Zhanjiang,Zhanjiang 524012,China;Guangdong State-Owned Huguang Farm Hospital,Zhanjiang 524000,China)
出处
《广东医科大学学报》
2018年第3期308-310,共3页
Journal of Guangdong Medical University
基金
湛江市科技攻关计划项目(No.2017B01039)
关键词
单一用药
联合用药
精神病复发
持续用药时间
single medication
drug combination
psychotic relapse
duration of medication
