摘要
目的探讨含阿莫西林克拉维酸钾的四联方案在根除胃幽门螺杆菌(H.pylori)感染中的临床疗效。方法选取2015年9月~2017年6月就诊于济南市中心医院且^(14)C-尿素呼气试验确诊H.pylori感染的门诊患者。随机分为A,B两组,A组给予含阿莫西林克拉维酸钾的四联方案,B组给予含阿莫西林的四联方案。均治疗2周,停药1个月后复查^(14)C-尿素呼气试验。结果共收集患者157例,A,B两组患者H.pylori根除率分别为94.5%,84.5%,两组差异有统计学意义(χ~2=4.042,P=0.044)。^(14)C-尿素呼气试验中DPM值与H.pylori根除成功率呈弱负相关(r=-0.359,P<0.05),但DPM值高低与不同内镜下表现差异不具有统计学意义(χ~2=12.028,P=0.443)。A组发生不良反应6例,B组发生不良反应8例,差异不具有统计学意义(χ~2=0.082,P=0.775),两组均未发生严重不良反应。结论含阿莫西林克拉维酸钾的四联方案对H.pylori的根除率优于含阿莫西林的四联方案,未见不良反应增加。
Objective To observe the clinical efficacy by using Quadruple therapy which contains Amoxicillin and Clavulanate Potassium,and to explore the role of Amoxicillin and Clavulanate Potassium in the eradication of H.pylori infection. Methods Patients with infection of H. pylori diagnosed by^（14）C-urea breath test in outpatient department of digestive of Jinan Central Hospital were enrolled in this study from Sept. 2015 to Jun. 2017. The patients were randomly divided into A and B two groups. Group A was treated with Quadruple therapy including Amoxicillin and Clavulanate Potassium; Group B was treated with Quadruple therapy including Amoxicillin. All the patients were treated with oral medicine for 2 weeks. The status of H. pylori infection was evaluated by the^（14）C-urea breath test performed one months later off the treatment. Results In total,there were 157 cases enrolled. The H. pylori eradication rate was 94. 5% in group A and 84. 5% in group B. The difference between two groups was statistically significant（ χ~2= 4. 042,P = 0. 044）.Statistical analysis showed that the DPM scores in^（14）C-urea breath test was negatively correlated with the eradication success rate of H. pylori（ r =-0. 359,P〈0. 05）,and no statistical significance difference were found between the DPM scores and the endoscopic finding（ χ~2= 12. 028,P = 0. 443）. Adverse reactions in group A occurred in 6 patients（ 8.2%）,while adverse reactions in group B occurred in 8 patients（ 9. 5%）. The difference between the two groups was not statistically significant（ χ~2= 0. 082,P = 0. 775）. Conclusion The eradication rate of H. pylori infection by using the Quadruple therapy including Amoxicillin and Clavulanate potassium is higher than using Amoxicillin,and the incidence of adverse reactions are not found increased.
作者
张艳敏
褚传莲
邹蕊霞
张琳璐
李芳
左芳
ZHANG Yanmin;CHU Chuanlian;ZOU Ruixia;ZHANG Linlu;LI Fang;ZUO Fang(Department of Internal Medicine,Weifang Medical University,Weifang 261053,China;Department of Digestive Medicine,Jinan,Central Hospital Affiliated to Shandong University;chool of Medicine and Life Sciences,University of Jinan-Shaadong Academy of Medical Sciences)
出处
《潍坊医学院学报》
2018年第2期81-84,共4页
Acta Academiae Medicinae Weifang
关键词
幽门螺杆菌
阿莫西林克拉维酸钾
根除治疗
DPM值
内镜下表现
Helicobacter pylori
Amoxicillin and clavulanate potassium
Eradication treatment
DPM value
Endoscopic finding
