摘要
目的双歧杆菌四联活菌辅助治疗对溃疡性结肠炎(ulcerative colitis,UC)患者脂质过氧化损伤指标、炎症因子和免疫功能的影响.方法选取浙江省衢州龙游县人民医院消化科2016-10/2017-11收治的110例UC患者,按照随机数字表法均分为两组:对照组55例,给予美色拉嗪治疗;观察组55例,在对照组的基础上给予双歧杆菌四联活菌治疗.治疗2 mo后,观察比较两组的总有效率、脂质过氧化损伤指标、炎症因子、外周T细胞亚群以及药物不良反应.结果治疗2 mo后,观察组总有效率(96.4%)明显高于对照组(85.5%),差异具有统计学意义(P<0.05).两组氧化型低密度脂蛋白、过氧化脂质、丙二醛、白介素-6、白介素-8、肿瘤坏死因子-α和超敏C-反应蛋白以及C D8+等指标较治疗前明显降低(P<0.05),且观察组比对照组降低更为显着(P<0.05);两组超氧化物歧化酶、CD4^+和CD4^+/CD8^+等较治疗前明显升高(P<0.05),且观察组比对照组升高更为显着(P<0.05).两组患者药物不良反应差异无统计学意义(P>0.05).结论双歧杆菌四联活菌辅助治疗UC患者的疗效显着,能够显着改善患者脂质过氧化状况和炎症因子水平,同时,还可以调节外周T细胞亚群,安全可靠,值得推广应用.
To evaluate the effect of adjuvant therapy with Bifidoba- cterium quadruple bacteria tablets on lipid peroxidation injury markers, inflammatory factors, and immune function in patients with ulcerative colitis. One hundred and ten patients with ulcerative colitis treated from October 2016 to November 2017 at People＇s Hospital in Longyou County were randomly divided into a control group （n = 55） and an observation group （n = 55）. Both groups were given mesalazine, and the observation group was additionally given Bifidobacterium quadruple bacteria tablets. After treatment for 2 mo, the total effective rate, lipid peroxidation injury indexes, inflammatory factors, peripheral T cell subsets, and adverse drug reactions were compared in the two groups. RESULT$ After treatment for 2 mo, the total effective rate of the observation group （96.4%） was significantly higher than that of the control group （85.5%; P 〈 0.05）. The levels of ox- LDL, LPO, MDA, IL-6, IL-8, TNF-α, hs-CRP, and CD8＋ T cells were significantly lower than those before treatment （P 〈 0.05）, and these indexes in the observation group were significantly lower than those of the control group （P 〈 0.05）. The levels of SOD, CD4＋ T cells, and CD4＋/CD8＋ ratio were significantly higher than those before treatment （P 〈 0.05）, and these indexes in the observation group weresignificantly higher than those of the control group （P 〈 0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P 〉 0.05）. CONCLUSION Adjuvant therapy with Bifidobacterium quadruple bacteria tablets in ulcerative colitis patients is significantly effective, which can effectively improve the levels of lipid peroxidation and inflammatory factors and regulate peripheral T cell subsets.
作者
张燕
吴绵勇
陈叶琴
Yan Zhang;Mian-Yong Wu;Ye-Qin(Department of Pharmacy,People＇s Hospital in Longyou County,Quzhou 324400,Zhejiang Province,Chin;Department of Gastroenterology,People＇s Hospital in Longyou County,Quzhou 324400,Zhejiang Province,China;Department of Obstetrics,First Affiliated Hospital in Zhejiang University,Hangzhou 310006,Zhejiang Province,China)
出处
《世界华人消化杂志》
CAS
2018年第22期1348-1354,共7页
World Chinese Journal of Digestology
关键词
溃疡性结肠炎
双歧杆菌四联活菌
脂质过氧化
炎症因子
免疫功能
Ulcerative colitis
Bifldobacterium quadruplebacteria tablet
Lipid peroxidation
Inflammatory factors
Immune function
