摘要
目的探讨阿德福韦酯联合水飞蓟宾治疗慢性乙型肝炎合并脂肪肝临床疗效。方法 96例慢性乙型肝炎合并脂肪肝患者,以随机数字表法分为对照组和观察组,每组48例。对照组给予阿德福韦酯单用,观察组在对照组基础上联用水飞蓟宾治疗。比较两组患者近期疗效,治疗前后乙肝病毒脱氧核糖核酸(HBV-DNA)、肝脏功能指标及血脂指标水平。结果观察组患者治疗总有效率93.75%显著高于对照组的72.92%,差异具有统计学意义(P<0.05)。治疗后12周,两组患者的谷草转氨酶(AST)、谷丙转氨酶(ALT)和HBV-DNA水平均低于治疗前,且观察组患者AST和ALT水平均显著低于对照组,差异具有统计学意义(P<0.05);两组患者治疗后12周HBV-DNA水平比较差异无统计学意义(P>0.05)。治疗后12周,两组患者的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均低于治疗前、高密度脂蛋白胆固醇(HDL-C)高于治疗前,且观察组患者的TG、TC、LDL-C水平均低于对照组、HDL-C高于对照组,差异具有统计学意义(P<0.05)。结论阿德福韦酯联合水飞蓟宾治疗慢性乙型肝炎合并脂肪肝可有效减轻相关症状体征,改善肝脏功能和血脂水平。
Objective To investigate the clinical effect of Adefovir Dipivoxil combined with Silybin in the treatment of chronic hepatitis B complicated with fatty liver. Methods 96 cases of chronic hepatitis B complicated with fatty liver were divided into control group and observation group according to the random number table method, 48 cases in each group. The control group was treated with Adefovir Dipivoxil alone, the observation group was treated with Silybin on the basis of the control group. The short-term effects, the levels of hepatitis B virus DNA（HBV-DNA）, liver function indexes and blood lipid levels before and after treatment between the two groups were compared. Results The total effective rate of the observation group was 93.75%, which was significantly higher than 72.92% of the control group, the difference was statistically significant（P〈0.05）. After treatment of 12 weeks, the levels of aspartate aminotransferase（AST）, alanine aminotransferase（ALT） and HBV-DNA in the two groups were all significantly lower than those before treatment, and the levels of AST and ALT in the observation group were significantly lower than those in the control group, the differences were statistically significant（P〈0.05）. There was no significant difference in the level of HBV-DNA between the two groups after treatment of 12 weeks（P〈0.05）. The levels of total cholesterol（TC）, triglyceride（TG） and low density lipoprotein cholesterol（LDL-C） in the two groups were significantly lower than those before treatment, and the high density lipoprotein cholesterol（HDL-C） was significantly higher than that before treatment, the levels of TG, TC and LDL-C in the observation group were significantly lower than those in the control group, and the HDL-C was significantly higher than that of the control group, the differences were statistically significant（P〈0.05）. Conclusion Adefovir Dipivoxil combined with Silybin in the treatment of chronic hepatitis B complicated with fatty liver can effectively alleviate the related symptoms and signs, improve liver function and blood lipid levels.
作者
王川雨
林尤直
WANG Chuan-yu;LIN You-zhi(Department of Internal Medicine,Hainan Provincial Judicial Hospital,Haikou 571199,China)
出处
《中国实用医药》
2018年第23期95-97,共3页
China Practical Medicine
