摘要
目的研究利培酮与齐拉西酮联合碳酸锂治疗双相情感障碍躁狂发作的疗效。方法将我院收治的72例双相情感障碍躁狂发作患者按照随机数表法分为A组和B组,各36例。A组给予利培酮联合碳酸锂治疗,B组给予齐拉西酮联合碳酸锂治疗。比较两组的临床疗效、治疗前、后的阳性及阴性症状量表(PANSS)评分及不良反应发生情况。结果 B组治疗总有效率与A组比较,差异不显著(P>0.05);治疗后,两组PANSS量表中阴性症状评分、阳性症状评分及一般精神病理量表评分均降低,且B组低于A组(P<0.05);B组体重增加、催乳素上升、锥体外系反应的发生率低于A组(P<0.05)。结论利培酮与齐拉西酮联合碳酸锂治疗双相情感障碍躁狂发作的疗效相当,但齐拉西酮联合碳酸锂的不良反应发生率更低,安全性更高。
Objective To investigate the efficacy of risperidone and ziprasidone combined with lithium carbonate in thetreatment of manic episode of bipolar affective disorder. Methods A total of 72 patients with manic episode of bipolaraffective disorder enrolled in our hospital were divided into group A and groupB according to the random number tablemethod, with 36 cases in each group. The group A was treated with risperidone combined with lithium carbonate, and thegroupB was treated with ziprasidone combined with lithium carbonate. The clinical effects, positive and negative symptomscale （PANSS） scores before and after treatment and incidences of adverse reactions were compared between the twogroups. Results There was no significant difference in the total effective rates of treatment in the two groups（P〉0.05）. Aftertreatment, the scores of negative symptoms, positive symptoms and general psychopathology scale in PANSS significantlydecreased in the two groups, and those of the group B were significantly lower than the groupA （P〈0.05）. The incidencesof weight gain, high prolactin and extrapyramidal reactions in the groupB were lower than those in the groupA （P〈0.05）.Conclusion The risperidone and ziprasidone combined with lithium carbonate in the treatment of manic episode of bipolaraffective disorder has similar efficacy. But the incidence of adverse reactions of the treatment by ziprasidone combined withlithium carbonate is lower and with higher safety.
作者
王福彦
WANG Fu-yan(Hanzhong Veteran Psychiatric Rehabilitation Hospital,Hanzhong 723000,China)
出处
《临床医学研究与实践》
2018年第25期23-24,共2页
Clinical Research and Practice
关键词
双相情感障碍躁狂发作
利培酮
齐拉西酮
碳酸锂
manic episode of bipolar affective disorder
risperidone
ziprasidone
lithium carbonate
