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细胞焦亡的分子机制及其在病毒感染中的作用 被引量:3

Molecular mechanism of pyroptosis and its role in viral infections
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摘要 细胞焦亡是一种新发现的细胞程序性死亡方式,兼有凋亡和坏死的特征。细胞焦亡的效应蛋白是Gasdermin-D,细胞受到刺激后,焦亡相关Caspases活化,水解Gasdermin-D,产物Gasdermin-D-N端结合到细胞膜上形成穿孔,造成细胞渗透性死亡、溶解,即发生焦亡,这个过程中伴随炎症因子的释放。本文就细胞焦亡的形态学特点、分子机制及其在病毒感染发病中作用的研究进展进行综述。 Pyroptosis is a newly discovered form of programmed cell death, and morphologically, it has the characteristics of both necrosis and apoptosis. Gasdermin-D is the executive protein in pyroptosis. Pyroptosis-related caspases were activated in cells after stimulation, and then caspases hydrolyzed to gasdermin-D. Subsequently, gasdermin-N domain combined to cytomembrane to form membrane pores. The pores disrupt the osmotic potential and cause cell swelling and eventual lysis. The process was also accompanied by releasing of inflammatory cytokines. This review focused on the morphology, molecular mechanism of pyroptosis and its role in viral infections.
作者 张克恭 王建 张野 黄长形 Zhang Kegong;Wang Jian;Zhan Ye;Huang Changxing(Department of Infectious Diseases,the Second Affiliated Hospital of Air Force Medical Univerisity,Xi' an 710038,China)
出处 《中华实验和临床病毒学杂志》 CAS CSCD 2018年第4期418-421,共4页 Chinese Journal of Experimental and Clinical Virology
关键词 细胞焦亡 炎症小体 Caspase-1/11 Gasdermin-D Pyroptosis Inflammasome Caspase-1/11 Gasdermin-D
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  • 1Zitvogel L,Kroemer G.The immune response against dying tumor cells:avoid disaster,achieve cure[J].Cell Death Differ,2008,15(1):1-2.
  • 2Fink SL,Cookson BT.Apoptosis,pyroptosis,and necrosis:mechanistic description of dead and dying eukaryotic cell[J].Infect Immun,2005,73(4):1907-1916.
  • 3Doitsh G,Galloway NL,Geng X,et al.Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection[J].Nature,2014,505(7484):509-514.
  • 4Chen Y,Smith MR,Thirumalai K,et al.A bacterial invasin induces macrophage apoptosis by binding directly to ICE[J].EMBO J,1996,15(15):3853-3860.
  • 5Mathan MM,Mathan VI.Morphology of rectal mucosa of patients with shigellosis[J].Rev Infect Dis,1991,13(Suppl 4):S314-318.
  • 6Zychlinsky A,Prevost MC,Sansonetti PJ.Shigella flexneri induces apoptosis in infected macrophages[J].Nature,1992,358(6382):167-169.
  • 7Hilbi H,Chen Y,Thirumalai K,et al.The interleukin 1beta-converting enzyme,caspase 1,is activated during Shigella flexneriinduced apoptosis in human monocyte-derived macrophages[J].Infect Immun,1997,65(12):5165-5170.
  • 8Hilbi H,Moss JE,Hersh D,et al.Shigella-induced apoptosis is dependent on caspase-1 which binds to Ipa B[J].J Biol Chem,1998,273(49):32895-32900.
  • 9Miao EA,Leaf IA,Treuting PM,et al.Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria[J].Nat Immunol,2010,11(12):1136-1142.
  • 10Danelishvili L,Bermudez LE.Analysis of pyroptosis in bacterial infection[J].Methods Mol Biol,2013,1004:67-73.

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