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龟龄集胶囊无机元素指纹图谱的建立及主成分分析 被引量:17

Construction of inorganic elemental fingerprint and principal component analysis of Guilingji Capsule
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摘要 目的建立龟龄集胶囊无机元素指纹图谱,评价龟龄集胶囊产品质量均一性,并寻找特征元素。方法采用微波消解法对样品进行前处理,ICP-MS法对龟龄集胶囊中Na、Mg、K、Ca、Cr、Mn、Fe、Co、Ni、Cu、Zn、Se、Mo、Sn共14种无机元素进行了定量测定,绘制无机元素质量分数分布图,并应用IBM SPSS Statistics 22.0软件对结果进行主成分分析(PCA)。结果建立了龟龄集胶囊的无机元素指纹图谱,10批次样品平均数相似度(夹角余弦值)、中位数相似度(夹角余弦值)均大于0.970,表明产品质量均一性良好。应用PCA选出4个主因子,得出Cr、Mn、Fe、Zn、Se为龟龄集胶囊的特征元素。结论建立的龟龄集胶囊无机元素指纹图谱,可为龟龄集胶囊的质量评价提供研究基础。 Objective To establish the inorganic elemental fingerprint of Guilingji Capsule and evaluate the uniformity of the product quality, and explore the characteristic elements in Guilingji Capsule. Methods The levels of 14 inorganic elements in 10 different production batches of Guilingji Capsule were determined by ICP-MS with microwave digestion for sample preparation. The content distribution curve of inorganic elements was plotted, and the principal component analysis(PCA) were analyzed with the IBM SPSS Statistics 22.0. Results Forteen kinds of inorganic elements were selected to establish fingerprint for describing and identifying the quality of Guilingji Capsule. The similarity(angle cosine value) were all more than 0. 970. Four main factors were selected by PCA. The PCA results showed that Cr, Mn, Fe, Zn, and Se might be the characteristic elements in Guilingji Capsule. Conclusion The inorganic elemental fingerprint of Guilingji Capsule can provide the research basis for quality control.
作者 史静超 张俊杰 高晓霞 张斌 秦雪梅 杜冠华 SHI Jing-chao;ZHANG Jun-jie;GAO Xiao-xia;ZHANG Bin;QIN Xue-mei;DU Guan-hua(Modem Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China;Department of Traditional Chinese Medicine,Shanxi University of Traditional Chinese Medicine,Jinzhong 030619,China;Scientific instrument center,Shanxi University,Taiyuan 030006,China;Shanxi Guangyuyuan Chinese Medicine Co.,Ltd.,Taigu 030800,China;Institute ofMateria Medica,Chinese Academy of Medical Sciences,Beijing 100050,China)
出处 《中草药》 CAS CSCD 北大核心 2018年第15期3619-3624,共6页 Chinese Traditional and Herbal Drugs
基金 山西省重点研发计划重点项目:山西传统名优中成药龟龄集的二次开发(201603D3113006)
关键词 龟龄集 电感耦合等离子体质谱 无机元素 指纹图谱 主成分分析 Na Mg K Ca Cr Mn Fe Co Ni Cu Zn Se Mo SN 特征元素 质量均一性 Guilingji inductively coupled plasma spectromter inorganic elemental fingerprint principal component analysis Na Mg K Ca Cr Mn Fe Co Ni Cu Zn Se Mo Sn characteristic elements uniformity of product quality
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