摘要
目的探讨脑室内持续泵入尿激酶联合腰大池引流治疗脑室出血的临床疗效。方法选取2012年1月‐2016年9月在该院就诊的104例脑室出血患者为研究对象,将其随机分为对照组(n=52)和治疗组(n=52)。对照组患者使用常规脑室外引流并使用尿激酶灌注,治疗组在对照组治疗基础上加行腰大池引流治疗。使用日常生活能力量表(ADL)、血肿清除情况和术后并发症发生情况评价两组患者治疗效果。结果对照组患者术后第2、7天血肿清除率分别为(33.2±4.8)%、(69.1±5.3)%,明显低于治疗组患者的(71.7±5.0)%、(91.4±2.3)%,比较差异有统计学意义(P<0.05);根据出院时ADL评分,出院时治疗组生活能力正常者比例明显高于对照组,而生活能力明显下降者比例明显低于对照组,差异均有统计学意义(P<0.05);对照组患者并发症发生率为21.15%(11/52),明显高于治疗组患者的7.69%(4/52),比较差异有统计学意义(P<0.05)。结论脑室内持续泵入尿激酶联合腰大池引流治疗脑室出血的临床效果显著,可改善患者预后。
【Objective】To investigate the clinical efficacy of intraventricular continuous infusion of urokinase combined with lumbar drainage in the treatment of intraventricular hemorrhage.【Methods】A total of 104 patients with intraventricular hemorrhage who were treated in our hospital from January 2012 to September 2016 were randomly divided into the control group（n =52） and the treatment group（n =52）. The patients in the control group were treated with conventional extraventricular drainage and infused with urokinase. On the basis of this, the treatment group was treated with lumbar drainage. The daily living ability scale（ADL）, the hematoma clearance, and the incidence of postoperative complications were used to evaluate the therapeutic effect.【Results】The hematoma clearance rate was（33.2 ± 4.8）% on the second day after operation and（69.1 ± 5.3）% on the 7 th day in the control group, and the hematoma clearance rate was（71.7 ± 5.0）% on the second day after operation,（91.4 ± 2.3）% on the 7 th day in the treatment group, the difference was statistically significant（P〈0.05）. According to the ADL score at discharge, the proportion of patients with normal living ability in the treatment group was significantly higher than that in the control group at the time of discharge, and the proportion of patients with significantly decreased living ability in the treatment group was significantly lower than that in the control group, and the difference was statistically significant（P〈0.05）; the incidence of complication was 21.15% in the control group and 7.69% in the treatment group, and the difference was statistically significant（P〈0.05）.【Conclusion】The continuous effect of intraventricular infusion of urokinase combined with lumbar drainage on intraventricular hemorrhage is significant, which can improve the prognosis of patients.
作者
宋钦
黄启锐
黎源
程巍
彭俏菁
SONG Qin;PENG Qirui;LI Yuan;CHENG Wei;PENG Qiaojing(Department of Neurosurgery,Humen Hospital of Dongguan,Dongguan,Guangdong 523900,China)
出处
《中国医学工程》
2018年第7期42-45,共4页
China Medical Engineering
关键词
脑室出血
脑室外引流
尿激酶
腰大池引流
intraventricular hemorrhage
extraventricular drainage
urokinase
lumbar drainage
