摘要
目的应用2型囊泡单胺转运体分子探针[^18F]-FP-（＋）-DTBZ对2型糖尿病患者胰腺进行显像，探究2型糖尿病患者的β细胞总量（BCM），并探讨胰头和胰体尾部作为靶区域在糖尿病BCM评价方面的价值。方法注射显像剂[^18F]-FP-（＋）-DTBZ 40 min后，对8例2型糖尿病患者和7例正常对照者行20 min PET-CT检查，以脾脏作为参考组织计算胰头和胰体尾部标准化摄取比值（SUV ratio, SUVR）。结果2型糖尿病组胰头部平均SUVR（1.72±0.47），与胰体尾部平均SUVR（1.85±0.41）无统计学差异，正常对照组胰头平均SUVR（2.54±0.57）和胰体尾部平均SUVR（2.73±0.41）无统计学差异。但2型糖尿病组胰头部平均SUVR和胰体尾部平均SUVR较正常对照组胰头部（P＝0.008 8）和胰体尾部（P＝0.001 2）显著减低。结论VMAT2靶点分子探针[^18F]-FP-（＋）-DTBZ可用于2型糖尿病患者BCM的评价。
ObjectiveThe aim of this study was to evaluate the β-cell mass （BCM） in patients with type 2 diabetes mellitus（T2D） by PET/CT using [^18F]-FP-（＋ ）-DTBZ, which is a vesicular monoamine transporter type 2 molecular probe. The feasibility of pancreatic head, body and tail as the target area was investigated for evaluation of the BCM in T2D.Methods15 subjects （8 with T2D, and 7 as control） were involved in this study with 20 min static PET imaging at 40 min post injection of [^18F]-FP-（＋ ）-DTBZ. The volume of interest （VOIs） of pancreatic head, body and tail were drawn and quantitatively assessed. Spleens were collected as reference tissue for SUVR calculation.ResultsSUVR in the pancreatic head （SUVR=1.72±0.47） and pancreatic body, tail （SUVR=1.85±0.41） in T2D group was no significant difference, and no significant difference was observed in the pancreatic head （SUVR=2.54±0.57） and pancreatic body, tail（SUVR=2.73±0.41） in control group as well. In T2D group, a significant decreased SUVR was found in pancreatic head （P=0.008 8） and pancreatic body and tail （P=0.001 2） compared with controls.ConclusionThe VMAT2 molecular probe [^18F]-FP-（＋ ）-DTBZ can be used to evaluate BCM in patients with T2D.
作者
姜东朗
孔艳艳
陆秀宏
李明
周维燕
华逢春
谢芳
管一晖
Jiang Donglang;Kong Yanyan;Lu Xiuhong;Li Ming;Zhou weiyan;Hua Fengchun;Xie Fang;Guan Yihui(PET Center,Huashan Hospital,Fudan University,Shanghai 200235,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2018年第8期638-642,共5页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金（81571345）
国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项（2016YFC1306403）
上海市自然科学基金与基础重大重点研究（16JC1420100、16JC1420502）
上海市自然科学基金（17511107103、17411953500）
复旦大学中科院苏州医工所“医工合作联合专项”（IDH2310002）
