摘要
采用2英寸刮膜分子蒸馏设备对双三氟虫脲关键中间体2-氯-3,5-二(三氟甲基)苯胺的提纯进行研究,考察了多种分离工艺参数对2-氯-3,5-二(三氟甲基)苯胺纯度和收率的影响,得到了最佳工艺条件:蒸馏温度为80℃,真空度为5 Pa,刮膜器转速450 r·min-1,产品纯度和收率分别达到96.9%和65.4%,该工艺具有操作简单,分离效果好,适合工业化生产等优点。
Wiped film molecular distillation device was used in the study of 2-chloro-3,5-bis（trifluoromethyl）aniline purification, and the effect of separating parameters on the purity and yield was investigated. The optimum molecular distillation process was achieved at 80 ℃with the scraper speed of 450 r·min-1 and vacuum of 5 Pa. Under such optimum conditions, the purity and yield were 96.9% and 65.4%, respectively. This process has the advantages of simple operation and effective separation, and is suitable for industrial production.
作者
刘玮
杨帆
邢冰梅
毛龙飞
姜玉钦
LIU WEI1, YANG Fan2, XING Bing-mei1, MAO Long-fei3, JIANG Yu-qin3.(1. China pharmaceutical health industry co. LTD, Beijing 100061, China; 2. Henan Institute of Geological Survey, Henan Zhengzhou 450000, China; 3. Henan Normal University, Henan Xinxiang 453007, China)
出处
《当代化工》
CAS
2018年第8期1553-1555,1559,共4页
Contemporary Chemical Industry
基金
2015年度河南省重点科技攻关项目
项目号:152102210285
