摘要
目的探讨舒筋活血汤对兔腰椎椎板切除术后硬膜外瘢痕形成的影响及意义。方法选取60只健康成年新西兰大白兔,随机分为舒筋活血汤组和空白对照组,每组30只。所有动物建立腰椎椎板切除模型,术后次日开始舒筋活血汤组给予舒筋活血汤灌胃,空白对照组腹腔注射生理盐水,剂量均为10mg/(kg·d)。分别于术后12周取材,进行组织学光镜观察并图像分析,用统计学方法比较各组数据差异。结果术后12周,舒筋活血汤组硬膜外瘢痕少,纤维组织粘连很轻;空白对照组硬膜外瘢痕组织生长明显,硬膜外有大量纤维组织。舒筋活血汤组改良Nussbaum标准组织学评分及硬脊膜瘢痕外周长度/硬膜囊周径比值低于空白对照组(P<0.01)。结论舒筋活血汤能有效减少腰椎术后硬膜外瘢痕形成,有可能改善临床病例手术后导致的症状。
Objective To explore the effects and significance of Shujin Huoxue Decoction on epidural scar formation after rabbit lumbar laminectomy. Methods Sixty healthy adult New Zealand rabbits were randomly assigned to Shujin Huoxue Decoction group and blank control group（n =30 per group）.All rabbits were used to establish models of lumbar laminectomy.On the next day after surgery,rabbits in the Shujin Huoxue Decoction group were intragastrically administered with Shujin Huoxue Decoction.Rabbits in the blank control group were intraperitoneally injected with physiological saline.All the dose was 10 mg/（kg·d）.Samples were collected 12 weeks after surgery for histological observation under the light microscope and image analysis.Statistical comparison of data was performed. Results Twelve weeks after surgery,epidural scar was less and fibrous tissue adhesion was light in the rabbits of the Shujin Huoxue Decoction group.Epidural scar tissues grew obviously and a large number of epidural fibrous tissues were found in the rabbits of the blank control group.Modified Nussbaum Standard Histology Score and the ratio of peripheral length of epidural scar to diameter of epidural sac were lower in the Shujin Huoxue Decoction group than in the blank control group（P〈 0.01）.Conclusion Shujin Huoxue Decoction can effectively reduce the formation of epidural scar after lumbar laminectomy,and may improve the symptoms after clinical surgery.
作者
陈宣煌
吴峰
蔡涵华
陈金辉
黄漫为
郑锦清
Chen Xuanhuang;Wu Feng;Cai Hanhua;Chen Jinhui;Huang Manwei;Zheng Jinqing(Department of Orthopedics,the Affiliated Hospital of Putian University,Putian 351100,Fujian,China;Department of Rehabilitation Medicine,the Affiliated Hospital of Putian University,Putian 351100,Fujian,China;Department of Orthopedics and Traumatology,the Affiliated Hospital of Putian University,Putian 351100,Fujian,China)
出处
《右江民族医学院学报》
2018年第4期315-318,共4页
Journal of Youjiang Medical University for Nationalities
基金
福建省自然科学基金项目(2016J01604)
福建省莆田市科技局项目(2018S3F003)
