摘要
目的观察2%米诺地尔搽剂联合梅花针治疗斑秃的临床疗效,评估安全性。方法收集门诊斑秃患者112例,随机分为治疗组50例,对照1组32例,对照2组30例。治疗组采用梅花针疗法联合2%米诺地尔搽剂外用,对照1组单纯予梅花针疗法,对照2组单纯外用2%米诺地尔溶液,均连续治疗3个月。结果治疗3个月后,治疗组、对照1组和对照2组的总有效率分别为90.00%、71.88%和70.00%,治疗组的总有效率明显高于对照1组和对照2组(χ2=4.527,P=0.033;χ2=5.195,P=0.023),对照1组和对照2组的总有效率差异无统计学意义(χ2=0.026,P=0.871)。治疗组及对照1组治疗过程中出现梅花针叩击轻度疼痛,无需特殊处理。对照2组无明显不良反应。结论2%米诺地尔搽剂联合梅花针治疗斑秃的临床疗效好,无明显不良反应。
Objective To investigate the clinical effect and safety of 2% minoxidil liniment combined with percussopunctator in the treatment of alopecia areata.Methods 112 cases with alopecia areata were enrolled in the study and randomly divided into treatment group（ 50 cases）,control group 1（ 32 cases） and control group 2（ 30 cases）. The treatment group were treated with percussopunctator combined with 2% minoxidil liniment for external use,the control group 1 were treated with percussopunctator therapy,and the control group 2 were treated with 2% minoxidil liniment. All groups were treated for 3 months.Results After three months of treatment,the total effective rate of the treatment group,the control group 1 and the control group 2 was 90.00%,71.88% and 70.00%,respectively.The total effective rate of the treatment group was significantly higher than those of the control group 1 and the control group 2（ χ^2= 4.527,P = 0.033; χ^2= 5.195,P = 0.023）.And there was no statistically significant difference in the total effective rate between the control group 1 and the control group 2（ χ^2= 0.026,P = 0.871）.The treatment group and the control group 1 showed mild pain while percussopunctator tapping during treatment,and no special treatment was needed.No significant side effects occurred in the control group 2. Conclusion 2% minoxidil liniment combined with percussopunctator has good clinical effect in the treatment of alopecia areata without severe side effects in the treatment of alopecia areata.
作者
麦少利
吴洁贞
MAI Shaoli;WU Jiezhen(Department of Pharmacy,Dongguan Rehabilitation Hospital,Dongguan 523119,China;Department of Dermatology,Dongguan Sixth People＇s Hospital,Dongguan 523008,China)
出处
《右江医学》
2018年第4期427-429,共3页
Chinese Youjiang Medical Journal
关键词
米诺地尔
梅花针
斑秃
minoxidil liniment
percussopunctator
alopecia areata
