摘要
目的研究阿司匹林联合头孢哌酮治疗急性脑卒中的疗效及对患者血清同型半胱氨酸(Hcy)、高密度脂蛋白(HDL-C)、肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)的影响。方法选取60例急性脑卒中患者作为研究对象,根据随机数字表法均分为对照组和研究组,患者均接受控制血压及血糖、改善血液循环、营养神经和抗血小板聚集等相关常规治疗,在此基础上对照组加服阿司匹林肠溶片,研究组加服阿司匹林肠溶片和头孢哌酮-舒巴坦。比较2组患者治疗前后神经功能、日常生活能力变化及血清Hcy、HDL-C、TNF-α和IL-8水平变化。结果治疗后2组患者的神经功能NIHSS评分均低于治疗前,且研究组低于对照组(P<0.05);2组患者日常生活能力BI指数均高于治疗前,且研究组高于对照组(P<0.05);2组患者的血清Hcy、TNF-α和IL-8水平均低于治疗前,且研究组低于对照组(P<0.05);2组患者的HDL-C水平均高于治疗前,且研究组高于对照组(P<0.05)。结论阿司匹林联合头孢哌酮-舒巴坦治疗急性脑卒中效果显著,能有效调节血清Hcy、HDL-C、TNF-α和IL-8水平,减轻炎症反应,改善血脂水平,促进患者神经功能和日常生活能力的恢复。
Objective To investigate the efficacy of aspirin combined with cefoperazone in the treatment of acute stroke and its effect on serum homocysteine （Hcy）,high density lipoprotein （HDL-C）,tumor necrosis factor-α（TNF-α）,and interleukin -8 （IL-8）. Methods 60 cases of acute stroke patients were selected as study subjects and divided into control group and study group according to random number table method.All the patients were treated with Aspirin Enteric-coated Tablets on the basis of the control of blood pressure and blood glucose,the improvement of blood circulation,nutrition nerves,anti-platelet aggregation and other related conventional treatment.The study group were given Aspirin Enteric-coated Tablets,Cefoperazone Sulbactam Capsules for treatment.The changes of neurological function,daily living ability and serum Hcy,HDL-C,TNF-αand IL-8 levels before and after treatment in both groups were observed and compared. Results NIHSS scores of neurological function after treatment in both groups were lower than before treatment,and the study group was lower than the control group,the difference was statistically significant （P〈0.05）;the BI index of both groups after treatment was higher than before treatment,and the research group was higher than the control group,the difference was statistically significant （P〈0.05）;the levels of serum Hcy,TNF-αand IL-8 in the 2 groups were lower than those before treatment,and the difference was statistically significant （P〈0.05）.The levels of HDL-C in both groups after treatment were higher than before treatment,and the study group was higher than the control group,the difference was statistically significant （P〈0.05）. Conclusion Aspirin combined with cefoperazone sulbactam has significant effect on acute stroke,and can effectively regulate serum Hcy,HDL-C,TNF-αand IL-8 levels,reduce inflammation,improve blood lipid levels,and promote neurological function and daily life ability recovery,It is worth to actively apply and promote.
作者
李扬
惠静
LI Yang;HUI Jing(Department of Neurology,Yulin First Hospital,Yulin 719000,China)
出处
《西北药学杂志》
CAS
2018年第5期668-671,共4页
Northwest Pharmaceutical Journal
基金
陕西省科技研究发展计划项目(编号:2011K12-67)
