摘要
骨桥蛋白(OPN)是一种分布广泛的分泌蛋白,主要参与整合素介导的细胞信号转导,在HCC的发生发展和转移过程中发挥重要作用。OPN在生物矿化和固有免疫中发挥重要作用,通过与整合素相互作用参与肿瘤生长和血管生成,通过多重信号转导诱导肝癌复发和转移。OPN与其他肿瘤标志物的联合检测评估,有利于提高早期HCC诊断敏感性。OPN抑制剂可能成为HCC治疗的新靶点,并有利于提高化疗药物的敏感性。总结了近年针对OPN的研究,对其生物学功能及其在HCC进展和诊疗中的作用进行介绍。
Osteopontin（OPN） is a widely distributed secretory protein and is involved in integrin-mediated cell signal transduction. It also plays an important role in the development,progression,and metastasis of hepatocellular carcinoma（HCC）. OPN plays a pivotal role in biomineralization and innate immunity,participates in tumor growth and angiogenesis by interacting with integrin,and induces the recurrence and metastasis of HCC via multiple signal transduction. Combined measurement of OPN and other tumor biomarkers can improve the sensitivity of early diagnosis of HCC. OPN inhibitors may serve as a new target for the treatment of HCC and can improve the sensitivity of chemotherapeutic drugs. This article summarizes the recent studies on OPN and introduces the biological function of OPN and its role in the progression and diagnosis and treatment of HCC.
作者
吴寒
李镇利
邢昊
王明达
吴孟超
杨田
WU Han;LI Zhenli;XING Hao(Department of Hepatobiliary Surgery,Eastern Hepatobiliary Surgery Hospital,The Second Military Medical University,Shanghai 200438,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2018年第9期1999-2003,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金(81472284
81172020
81372262)
上海市慈善慢跑课题(20130007)
关键词
癌
肝细胞
骨桥蛋白质
综述
carcinoma
hepatocellular
osteopontin
review
