摘要
目的观察灯盏细辛注射液联合心肌康颗粒治疗病毒性心肌炎的临床疗效。方法选取2011年7月—2017年2月在湖北医药学院附属人民医院诊治的病毒性心肌炎患者128例为研究对象,随机将入组患者分为对照组和治疗组,每组各64例。对照组口服心肌康颗粒,1袋/次,2次/d;治疗组在对照组治疗的基础上静脉滴注注射用灯盏细辛注射液,30 m L加入5%葡萄糖溶液250 m L,1次/d。两组患者均连续治疗1个月。观察两组患者临床疗效和心电图疗效,比较治疗前后两组患者心肌酶谱和血清炎症因子水平。结果治疗后,对照组患者临床总有效率分别为73.44%、90.63%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者磷酸肌酸激酶(CK)、心肌肌钙蛋白Ⅰ(c Tn I)、肌酸激酶同工酶(CK-MB)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组心肌酶谱水平显著低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、超敏C反应蛋白(hs-CRP)水平均明显下降,超氧化物歧化酶(SOD)水平明显升高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组血清炎性因子水平显著优于对照组,两组比较差异具有统计学意义(P<0.05)。结论灯盏细辛注射液联合心肌康颗粒具有较好的临床疗效,能够改善病毒性心肌炎心肌酶谱,抑制炎症因子表达,具有一定的临床推广价值。
Objective To observe the clinical efficacy of Dengzhanxixin Injection combined with Xinjikang Granules in treatment of viral myocarditis. Methods Patients（128 cases） with viral myocarditis in Affiliated Hospital of Hubei Medical College from July 2011 to February 2017 were randomly divided into control and treatment groups, and each group had 64 cases. Patients in the control group were po administered with Xinjikang Granules, 1 bag/time, twice daily. Patients in the treatment group were iv administered with Dengzhanxixin Injection on the basis of the control group, 30 m L added into 5% glucose solution 250 m L, once daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacy and the electrocardiogram efficacy were evaluated, and myocardial enzymes and the serum levels of inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control group and treatment group were 73.44% and 90.63%, respectively, and there were differences between two groups（P〈 0.05）. After treatment, the CK, c TnⅠ, and CK-MB levels in two groups were significantly decreased（P〈 0.05）. And these myocardial enzymes levels in the treatment group were significantly lower than those in the control group（P〈 0.05）. After treatment, the levels of TNF-α, IL-6, and CRP in two groups were significantly decreased, but the levels of SOD in two groups were significantly increased, and the difference was statistically significant in the same group（P〈 0.05）. And the serum levels of inflammatory factors in the treatment group were significantly better than those in the control group（P〈 0.05）. Conclusion Dengzhanxixin Injection combined with Xinjikang Granules has clinical curative effect in treatment of viral myocarditis, can improve the expression of myocardial enzymes and inflammatory factors, which has a certain clinical application value.
作者
范群雄
赵继先
张焕鑫
李波
吴三五
FAN Qun-xiong;ZHAO Ji-xian;ZHANG Huan-xin;LI Bo;WU San-wu(Department of Cardiology,Shiyan People＇s Hospital（Affiliated People＇s Hospital of Hubei Medical College）,Shiyan 442000,China)
出处
《现代药物与临床》
CAS
2018年第8期1928-1931,共4页
Drugs & Clinic
关键词
灯盏细辛注射液
心肌康颗粒
病毒性心肌炎
心肌酶谱
炎症因子
Dengzhanxixin Injection
Xinjikang Granules
viral myocarditis
myocardial enzyme
inflammatory factor
