摘要
目的探讨振源胶囊联合丙米嗪治疗抑郁症伴焦虑症状患者的临床疗效。方法选取2015年11月—2017年7月洛阳市第五人民医院收治的抑郁症伴焦虑症状患者120例,随机分为对照组(60例)和治疗组(60例)。对照组患者口服盐酸丙米嗪片,起始剂量为50 mg/d,3~5 d后根据情况调整药量,最高剂量为200 mg/d。治疗组在对照组基础上口服振源胶囊,2粒/次,3次/d。两组患者连续治疗8周。观察两组患者临床疗效,同时比较治疗前后两组患者汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分。结果治疗后,对照组临床有效率为73.33%,显著低于治疗组的93.33%,两组比较差异具有统计学意义(P<0.05)。治疗后1、2、4和8周,两组HAMD和HAMA评分均比治疗前显著降低(P<0.05),同组比较差异具有统计学意义(P<0.05);且治疗后治疗组HAMD和HAMA评分比同期对照组降低更明显,两组比较差异具有统计学意义(P<0.05)。结论振源胶囊联合丙米嗪治疗抑郁症伴焦虑症状可有效减轻抑郁、焦虑症状,提高患者睡眠质量,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Zhenyuan Capsules combined with imipramine in treatment of depression with anxiety. Methods Patients（120 cases） with depression associated with anxiety in Luoyang Fifth People＇s Hospital from November 2015 to July 2017 were randomly divided into control（60 cases） and treatment（60 cases） groups. Patients in the control group were po administered with Imipramine Hydrochloride Tablets, the initial dose was 50 mg/d, and adjusted the dosage according to the actual situation after 3 — 5 d, and the maximum dose was 200 mg/d. Patients in the treatment group were po administered with Zhenyuan Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the HAMD and HAMA scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 73.33%, which was significantly lower than 93.33% in the treatment group, and there were differences between two groups（P〈 0.05）. After treatment for 1, 2, 4, 8 weeks, the HAMD and HAMA scores in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈 0.05）. And the HAMD and HAMA scores in the treatment group after treatment were significantly lower than those in the control group of the same period, with significant difference between two groups（P〈 0.05）. Conclusion Zhenyuan Capsules combined with imipramine in treatment of depression with anxiety can relieve the symptoms of depression and anxiety, improve sleep quality, which has a certain clinical application value.
作者
闫金海
耿小雨
YAN Jin-hai;GENG Xiao-yu(Department ofTCM,Luoyang Fifth People＇s Hospital,Luoyang 471000,China;Department of Internal Medicine,the Fifth Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000 China)
出处
《现代药物与临床》
CAS
2018年第8期2108-2111,共4页
Drugs & Clinic
