摘要
[目的]探讨血清C反应蛋白（CRP）、D-二聚体（D-dimer）水平变化对高脂血症性急性胰腺炎（HLAP）的早期诊断价值.[方法]检测并比较70例HLAP患者（A组）、70例非HLAP患者（NHLAP,B组）的血脂,CRP、D-dimer水平变化趋势,并采用受试者工作曲线（ROC）求取其鉴别诊断HLAP与NHLAP患者的临床价值.[结果]A组患者的外周血总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）水平均显著高于B组（P〈0.05）;A组患者的CRP水平显著高于B组（P〈0.05）;两组患者的D-dimer水平相比较差异无显著性（P〉0.05）;利用两组患者的CRP水平绘制ROC曲线,求取的鉴别诊断患者的最佳诊断临界值为118.5 mg/L,对应点的灵敏度为84.61％、特异度为89.27％、漏诊率为15.39％、误诊率为10.73％、ROC曲线下面积AUC值为0.867.[结论]血清CRP对于鉴别诊断HLAP和NHLAP患者具有一定的临床价值,D-dimer对于鉴别诊断NLAP和NHLAP患者无意义.
[Objective]To investigate the clinical value of serum C-reactive protein （CRP） and D-dimer levels in the early differential diagnosis of hyperlipidemic acute pancreatitis （HLAP）. [Methods]The blood lipids, CRP and D-dimer levels of 70 patients with HLAP （group A） and 70 patients with non-hyperlipidemic a- cute pancreatitis （NHLAP,group B） were examined and compared. The receiver＇s working curve （ROC） was used to obtain the clinical value of differential diagnosis of HLAP and NHLAP patients.[Results]The levels of total cholesterol （TC）,triglyceride （TG） and low-density lipoprotein cholesterol （LDL-C） in the peripheral blood of group A were significantly higher than those of group B （ P〈0.05）. The level of CRP in group A was significantly higher than that in B group （ P -0.05）. There was no significant difference in D-dimer levels between the two groups （ P 〉0.05）. The ROC curve was drawn from the CRP levels of two group, and the optimal diagnostic threshold for the differential diagnosis was 118. Smg/L. The difference between the two groups was statistically significant （ P 〉0.05）. The sensitivity of the corresponding point was 84.61%, the specificity was 89.27%, the missed diagnosis rate was 15.39%, the misdiagnosis rate was 10.73%, and the area under the ROC curve （AUC） was 0.867. [Conclusion]Serum CRP has a certain clinical value for the dif- ferential diagnosis of HLAP and NHLAP patients, D-dimer is not meaningful for the differential diagnosis of NLAP and NHLAP patients.
作者
李佳
尹庆霞
LI Jia;YING Qing-xia(The 903 Hospital of Jiangyou City,621700 Sichuan Province)
出处
《医学临床研究》
CAS
2018年第8期1530-1532,共3页
Journal of Clinical Research
