摘要
目的探究抗焦虑抑郁药治疗功能性腹痛综合征(FAPS)的临床疗效,验证焦虑抑郁精神心理因素与FAPS的相关性。方法将67例FAPS患者随机分为试验组(34例)和对照组(33例)。两组患者均给予抑酸、促动力等个性化常规治疗,试验组在常规治疗基础上加用盐酸帕罗西汀(赛乐特),随访4周。在治疗0、4周时,分别对两组患者腹痛视觉模拟评分(VAS)、PHQ-9抑郁症筛查量表评分、GAD-7焦虑症筛查量表评分进行比较。结果治疗后,两组患者的腹痛VAS评分、PHQ-9评分、GAD-7评分均较治疗前下降,且试验组低于对照组(P<0.05)。结论盐酸帕罗西汀对改善伴有焦虑抑郁情绪障碍的FAPS患者的腹痛症状及情绪障碍具有显著疗效。
Objective To explore the clinical efficacy of anti-anxiety and anti-depression drugs in the treatment of functional abdominal pain syndrome（FAPS）, and to verify the correlation between anxiety and depression psychological factors and FAPS. Methods Sixty-seven FAPS patients were randomly divided into experimental group（34 cases） and control group（33 cases）. All patients were given individualized routine treatment such as acid suppression and power stimulation, and the experimental group was given paroxetine hydrochloride（celote） on the basis of routine treatment. The patients were followed up for 4 weeks. At 0 and 4 weeks for treatment, the visual analogy scores（VAS） of abdominal pain,the PHQ-9 depression screening scale scores and the GAD-7 anxiety screening scale（GAD-7） scores were compared between the two groups. Results After treatment, the VAS scores of abdominal pain, PHQ-9 scores and GAD-7 scores in both groups were lower than those before treatment, and those of the experimental group were lower than the control group（P〈0.05）. Conclusion Paroxetine hydrochloride has a significant effect on improving abdominal pain symptoms and emotional disorders in patients with FAPS accompanied by anxiety and depression.
作者
李康
魏良洲
林立波
赵文睫
李玉莉
LI Kang;WEI Liang-zhou;LIN Li-bo;ZHAO Wen-jie;LI Yu-li(Qingdao University,Qingdao 266071;Gastroenterology Department,the Affiliated Hospital of Qingdao University,Qingdao 266000,China)
出处
《临床医学研究与实践》
2018年第26期14-16,共3页
Clinical Research and Practice
关键词
功能性腹痛综合征(FAPS)
焦虑
抑郁
盐酸帕罗西汀片
functional abdominal pain syndrome （FAPS）
anxiety
depression
paroxetine hydrochloride tablet
