摘要
目的探讨右美托咪定在开颅术患者全身麻醉过程中的应用价值。方法收集2013年1月至2017年8月,100例患者在该院接受开颅术进行治疗。该研究以上述患者作为研究对象,并回顾性分析其临床病历资料。根据不同的麻醉方法,将其分为试验组(n=52)与对照组(n=48)。其中对照组患者使用0.9%NaCl溶液辅助全身麻醉,而试验组患者使用右美托咪定辅助全身麻醉,两组患者其余麻醉方案一致。观察两组患者循环功能及疼痛评分、术后唤醒时间、躁动评分等指标情况,并评价两组患者的麻醉效果及并发症发生率。结果术前,两组患者的循环功能差异无统计学意义(P>0.05),而在术中、术后6h,试验组患者循环功能各指标(心率、平均动脉压、收缩压)优于对照组(P<0.05);术后6h,试验组患者相关指标值(疼痛评分、术后唤醒时间及躁动评分)明显小于对照组(P<0.05);与对照组比较,试验组患者麻醉总有效率更高(P<0.05);并发症(视物模糊、寒战、恶心呕吐等)发生方面,两组差异无统计学意义(P>0.05)。结论开颅术患者全身麻醉中使用右美托咪定,不仅能改善患者循环功能,同时也降低患者疼痛及躁动反应,并加快患者的苏醒。麻醉效果确切,且发症少,患者易耐受。
Objective To study on the application value of dexmedetomidine in the process of general anesthesia for the craniotomy patients.Methods The 100 patients were treated in our hospital using craniotomy from January 2013 to August 2017.These patients were considered as study objects and their clinical data were analyzed retrospectively.According to the different anesthesia methods,they were grouped into experimental group（n=52）and control group（n=48）.0.9%NaCl solution was used for auxiliary anesthesia in the control group,and the patients were used with dexmedetomidine for auxiliary anesthesia in the experimental group.The indexes about the circulation function were observed,also including the time of waking up,pain score,and agitation score.Besides,the anesthesia effects and the incidence of complications were also evaluated between these groups.Results Before the operation,there were no difference between these groups（P〉0.05）.However,during operation and after operation for 6 hours,the circulatory function indexes（heart rate,mean arterial pressure,systolic blood pressure（SBP）were better than the control group in the experimental group（P〈0.05）;After the operation for 6 hours,the related index values（pain score,postoperative wake time and agitation score）in the experimental group were significantly less than that of the control group（P〈0.05）;Compared with control group,the ratio of total efficiency about anesthesia undergoing is higher in the experimental group（P〈0.05）;The difference about was not significant about adverse reactions（blurred vision,shiver,nausea and vomiting,etc.）between these two groups（P〉0.05）.Conclusion Dexmedetomidine is used in the process of general anesthesia for the craniotomy patients,and it not only can improve the circulation function of patients,but also reduce pain and the reaction of agitation,and improve recovery for the patients.Furthermore,the efficacy of anesthetic is better,with fewer complications,tolerated by the patients.Therefore,the drug is worth to further promotion in clinic.
作者
张庆华
高东雯
朱洪生
ZHANG Qinghua;GAO Dongwen;ZHU Hongsheng(Department of Anesthesiology,the Affiliated Longhua Hospital of Shanghai Uniwersity of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《检验医学与临床》
CAS
2018年第18期2773-2776,共4页
Laboratory Medicine and Clinic
基金
上海中医药大学预算内项目(2015YSN35)
关键词
右美托咪定
开颅术
全身麻醉
应用价值
dexmedetomidine
craniotomy
general anesthesia
application value
