摘要
目的:观察厄贝沙坦氢氯噻嗪联合美托洛尔治疗慢性心力衰竭及对血清IL-12与BNP水平的影响。方法:选取石河子市人民医院2013年1月-2017年1月收治入院的100例慢性心力衰竭患者作为研究对象,并将其分为两组,对照组采用常规药物治疗,观察组患者在常规药物治疗的基础上采用厄贝沙坦氢氯噻嗪片联合美托洛尔治疗,两组均治疗3个月。检测两组患者治疗前后白介素-12(IL-12)与B型脑钠肽(B-type natriuretic peptide,BNP)水平;观察治疗后24小时心率变异时域指标,并对治疗前与治疗后患者的心功能情况予以评定,主要测定左心室射血分数、左心室舒张末期内径、左心室收缩末期内径变化。结果:与治疗前相比,两组患者血清BNP和IL-12水平均明显降低(P<0.05);经过治疗后,观察组患者的血清BNP和IL-12水平明显低于对照组,且差异有统计学意义(P<0.05);观察组患者治疗后24小时的SDNN、SDANN、RMSSD、PNN50等心率变异时域指标长于对照组,且两组有统计学意义(P<0.05);与治疗前相比,两组患者左心室射血分数、左心室舒张末期内径、左心室收缩末期内径均有所改善(P<0.05);经过治疗后,观察组患者的左心室射血分数明显高于对照组,观察组患者的左心室舒张末期内径与左心室收缩末期内径的下降幅度明显优于对照组(P<0.05)。结论:厄贝沙坦氢氯噻嗪联合美托洛尔对慢性心力衰竭的治疗效果显著,能够有效降低血清IL-12与BNP水平,延长心率变异时域,改善心功能,值得临床推广。
Objective： To investigate the effect of irbesartan hydrochlorothiazide combined with metoprolol on the levels of serum IL-12 and BNP in patients with chronic heart failure.Methods：One hundred patients with chronic heart failure admitted in our hospital from January 2013 to January 2017 were selected and divided into two groups.The patients in the control group were treated with conventional drugs.The patients in the observation group were treated with conventional drugs and irbesartan hydrochlorothiazide tablets combined with metoprolol treatment.The two groups were treated in three months.（IL-12） and B-type natriuretic peptide （BNP） were measured before and after treatment.Heart rate variability time-domain indexes in 24 hours after treatment was observed and cardiac function was compared between pre-treatment and post-treatment, including left ventricular ejection fraction,left ventricular end diastolic dimension and left ventricular end systolic diameter.Results： The levels of serum BNP and IL-12 were significantly lower in the two groups than pre-treatment（P〈0.05）.After treatment, the levels of serum BNP and IL-12 in observation group were significantly lower than those in control group（P〈0.05）.SDNN, SDANN,RMSSD, PNN50 in observation group after treatment for 24 hours were longer than those in control group（P〈0.05）.The left ventricular ejection fraction （LVEF）, left ventricular end diastolic diameter （LVED）, left ventricular end systolic diameter were better than before in both group（P〈0.05）.The left ventricular ejection fraction of patients in observation group was significantly higher than that of control group.The left ventricu-lar end diastolic diameter and left ventricu-lar end systolic diameter of the left ventricle were significantly higher than those of control group（P〈0.05）.Conclusion：Irbesar-tan hydrochlorothiazide combined with metoprolol can significantly reduce the levels of serum IL-12 and BNP, prolong heart rate variability and improve cardiac function, which is worthy of clinical application.
作者
刘丹
郭萍
韩艺辉
LIU Dan;GUO Ping;HAN Yi-hui(Cardiovascular Medicine Department,The People＇s Hospital of Xinjiang Shihezi,Xinjiang Shihezi,832000;Cardiac Function Department,The People＇s Hospital of Bozhou,Xinjiang BoLe,833400)
出处
《农垦医学》
2018年第3期201-205,共5页
Journal of Nongken Medicine
