摘要
狼疮性肾炎(LN)是系统性红斑狼疮(SLE)最常见且严重的并发症之一,也是导致SLE患者死亡的主要因素。目前对于LN的治疗主要有糖皮质激素(GCs)、免疫抑制剂、生物制剂、多靶点治疗及血浆置换等治疗手段,GCs及免疫抑制剂已普遍应用于临床,随着对LN发病机制的不断深入,多靶点治疗及生物靶向治疗越来越得到人们重视,已成为目前主要的研究热点。但不同治疗方法的疗效及不良反应各异,需结合患者自身情况选择最佳治疗方式从而提高患者生存率。
Lupus nephritis（LN） is one of the most common and serious complications of systemic lupus erythematosus（SLE） and a key factor leading to death in patients with SLE.At present,the treatment of LN mainly includes glucocorticoids,immunosuppressants,biological agents,multi-target therapy,and plasma exchange.Treatments such as glucocorticoids and immunosuppressive agents have been widely used in clinical practice.As the deepening of the research on LN pathogenesis,multi-target therapy and bio-targeted therapy are getting more and more attention,and have become the main research focus.However,different treatment methods have different curative effects and adverse reactions.It is necessary to select the best treatment method considering the patient＇s own situation so as to improve the survival rate.
作者
王幸
张祥贵
WANG Xing;ZHANG Xianggui(Department of Nephrology,the Fifth Affiliated（Zhuhai）Hospital of Zunyi Medical University,Zhuhai 519100,China)
出处
《医学综述》
2018年第17期3419-3423,3429,共6页
Medical Recapitulate
基金
贵州省卫生计生委科学技术基金项目(gzwjkj2017-1-025)
关键词
狼疮性肾炎
免疫抑制剂
多靶点治疗
生物制剂
Lupus nephritis
Immunosuppressants
Multi-target treatment
Biological agents
