摘要
目的探讨胎盘多肽治疗原发免疫性血小板减少症(Immune thrombocytopenia,ITP)的临床疗效。方法我院接受治疗的ITP患者96例,按随机数字表法分为胎盘多肽组与泼尼松组各48例,泼尼松组给予醋酸泼尼松治疗,胎盘多肽组在泼尼松组基础上联合胎盘多肽治疗。观察两组治疗前后PAIg A、PAIg G、PAIg M等血小板抗体,CD3^+、CD4^+、CD8^+等T细胞,产板巨核、巨核细胞、网织血小板水平,不良反应及临床疗效。结果治疗后,胎盘多肽组PAIg A、PAIg G、PAIg M、CD3^+CD8^+、巨核细胞、网织血小板水平均低于泼尼松组,CD3^+、CD3^+CD4^+、CD4^+/CD8^+、产板巨核水平均高于泼尼松组(P<0.05)。胎盘多肽组总有效率高于泼尼松组(P<0.05)。治疗期间两组均未发生明显不良反应。结论胎盘多肽治疗ITP可有效纠正患者机体免疫失衡,降低血小板抗体水平,增加血小板数量,疗效确切,安全可靠,值得临床推广应用。
Objective Objectives To investigate the clinical curative effect of placental peptide in the treatment of patients with immune thrombocytopenia （ITP）.Methods Ninety-six ITP patients admitted to our hospital were divided into placental peptide and prednisone acetate groups ,48 in each group based on a random number table.The prednisone acetate group was treated with predni-sone acetate while the placental peptide group was treated with prednisone acetate and placental peptide.The levels of PAIgA,PAIgG, PAIgM and other platelet antibodies,CD3＋ ,CD4＋ ,CD8＋ and other T cells,giant nuclear cell that produces platelets,megakaryocyte and reticulated platelet were observed before and after treatment in the two groups.The adverse reaction and clinical efficacy were compared between the two groups. Results After treatment, the levels of PAIgA, PAIgG, PAIgM, CD3＋CD8＋, megakaryocyte and reticulated platelet in the placental peptide group were lower than those in the prednisone acetate group while the levels of CD3＋, CD3＋CD4＋, CD4＋/CD8＋ and giant nuclear cell that produces platelets were higher in placental peptide group than those in the prednisone acetate group （P 〈0.05 ）. The total effective rate of the placental polypeptide group was greater than that of the prednisone group.During the treatment,no obvious adverse reaction was found in the two groups.Conclusion Placenta polypeptide can effectively correct the pa-tientsy immune imbalance, reduce the platelet antibody levels and increase the platelet number in ITP patients.Its curative effect is obvi-ous and the treatment is safe and reliable.It is worthy of clinical application.
作者
谭建军
TAN Jian-jun(Santai Hospital of Traditional Chinese Medicine,Santai 621100,Sichuan,China)
出处
《实用医院临床杂志》
2018年第5期110-113,共4页
Practical Journal of Clinical Medicine
关键词
胎盘多肽
泼尼松
原发免疫性血小板减少症
免疫失衡
疗效
Placenta polypeptide
Prednisone
Wmary immune iJirombocytopenia
Immune imbal肋c e
Curative effect
