摘要
目的分析中国2010-2017年新生儿破伤风（Neonatal tetanus,NT）的流行病学特征。方法通过中国疾病预防控制信息系统收集2010-2017年发病的实验室诊断和临床诊断NT,采用描述性方法进行分析。结果 2010-2017年共报告3 992例NT,年均发病率为0.032‰,发病率从2010年的0.058‰下降至2017年的0.0059‰;2011-2017年市级和2017年县级发病率均〈1‰;男、女性发病率分别为0.039‰、0.024‰。在所有病例中,广东、广西、新疆、浙江和云南的报告病例数（2 488例）占62.32%;2010-2015年每周均有病例报告;发病年龄中位数为8d（1-28d）。NT死亡272例,病死率为6.81%;〈9天龄、9-14天龄和〉14天龄的病死率分别为8.88%、4.80%和3.97%;发病到死亡的时间间隔中位数为3d（0-32d）。结论中国NT发病呈下降趋势,且发病年龄越小,病死率越高。建议进一步评价监测系统质量和以县级为单位实现消除NT的状况。
Objective To analyze the epidemiology of neonatal tetanus（ NT） in China from 2010 to2017. Methods We obtained reports of laboratory-confirmed and clinical-confirmed NT cases occurring during 2010-2017 through the Chinese Disease Control and Prevention Information System and conducted a descriptive analysis. Results During 2010-2017,a total of 3 992 NT cases were reported,for an average incidence of 0. 032‰. The annual incidence decreased from 0. 058‰ in 2010 to 0. 0059‰ in 2017.Incidence rates were under 1‰ at prefecture level from 2011 through 2017,and at county level in 2017.The incidence was 0. 039‰ in males and 0. 024‰ in females; 62. 32%（ 2 488 cases） of NT cases were reported from Guangdong,Guangxi,Xinjiang,Zhejiang,and Yunnan provinces/regions. NT was reported every week during 2010-2015. The median age of onset was 8 days（ range： 1-28 days）. A total of272 fatal cases were reported,for an average case fatality rate of 6. 81%. Case fatality rates for 9,9-14,and 14-day-olds were 8. 88%,4. 80%,and 3. 97%,respectively. The median time interval from onset to death was 3 days（ range： 0-32 days） among death cases. Conclusions NT incidence decreased between 2010 and 2017. Younger cases had higher case fatality rates. We should evaluate the surveillance system and NT elimination status at county levels.
作者
宁桂军
高源
夏伟
吴丹
李军宏
李艺星
邵祝军
尹遵栋
Ning Guijun;Gao Yuan;Xia Wei;Wu Dan;Li Junhong;Li Yixing;Shao Zhujun;Yin Zundong(Department of National Im-munization Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China;National Institute of Communicable Disease Control and Prevention,Chines＇e Center for Disease Control and Prevention,Beijing 102206,China)
出处
《中国疫苗和免疫》
北大核心
2018年第4期379-382,共4页
Chinese Journal of Vaccines and Immunization
关键词
新生儿破伤风
流行病学
消除
Neonatal tetanus
Epidemiology
Elimination
