摘要
采用室温搅拌法制备了金属有机骨架材料ZIF-8.通过X射线粉末衍射（XRD）、红外光谱（IR）、N2吸附-脱附、透射电子显微镜（TEM）和扫描电子显微镜（SEM）对所得样品进行了表征分析,并以苯扎氯铵为杀菌药物模型,研究了ZIF-8对苯扎氯铵这种药物的载药及体外释药性能.表征结果显示,制备的ZIF-8是一种具有规则十二面体方钠石结构的晶体,BET比表面积为2 643m2/g.载药及体外释放实验表明,ZIF-8对浓度为4mmol/L苯扎氯铵的载药量为43g/100g ZIF-8,载药后的ZIF-8在释放90h后,释放率达84.82%,说明ZIF-8对苯扎氯铵有较好的缓释性能.
The metal organic skeleton material ZIF-8 was prepared by stirring at room temperature.The samples were characterized by X-ray powder diffraction（XRD）,infrared spectroscopy（IR）,N2 adsorption-desorption,transmission electron microscopy（TEM）and scanning electron microscopy（SEM）.The drug loading and release properties in vitro of ZIF-8 were studied by using benzalkonium chloride as bactericidal drug model.The characterization results showed that ZIF-8 prepared was a crystal with a dodecahedral sodalite structure and its BET was 2 643 m2/g.The drug loading and release test in vitro showed that benzalkonium chloride loading capacity of ZIF-8 was 43 g/100 g ZIF-8 using 4 mmol/L benzalkonium chloride.The drug release rate of benzalkonium chloride loaded ZIF-8 was 84.82%in 90 h,indicating that ZIF-8 carrier had good sustained-release performance for benzalkonium chloride.
作者
高金龙
贾云婷
谷娜
赵扩林
王奎涛
张炳烛
GAO Jin-long;JIA Yun-ting;GU Na;ZHAO Kuo-lin;WANG Kui-tao;ZHANG Bing-zhu(College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang 050018,China;Key Laboratory of Medicinal Molecular Chemistry in Hehei Province,Shijiazhuang 050018,China;School of Science,Hebei University of Science and Technology,Shijiazhuang 050018,China;Hebei Chemical and Pharmaceutical College,Shijiazhuang 050026,China)
出处
《分子科学学报》
CAS
CSCD
北大核心
2018年第4期324-330,共7页
Journal of Molecular Science
基金
河北省自然科学基金资助项目(B2016208054)
关键词
ZIF-8
苯扎氯铵
载药量
药物缓释
ZIF-8
henzalkonium chloride
drug loading
sustained release
