摘要
为了防控以腹泻、脱水和消瘦为特征的羊结肠小袋虫病,试验根据羊结肠小袋虫滋养体药物杀灭试验的绝对致死浓度(LC100),筛选甲硝唑、血虫净和土霉素进行半数致死浓度(LC50)测定试验。结果表明,甲硝唑、血虫净和土霉素对羊结肠小袋虫2h的半数致死浓度(LC50)分别为0.213、0.418、0.523 mg/mL,12h的半数致死浓度(LC50)分别为0.056、0.107、0.149mg/mL。说明甲硝唑是体外杀灭羊结肠小袋虫滋养体的高效药物。
In order to prevent and control sheep balantidiasis coli characterized by diarrhea, dehydration and emaciation,metronidazole, diminazene and oxytetraeycline were selected to determine the median lethal concentration （LC50） in this paper,based on the absolute lethal concentration （LC100） of the drugs against trophozoite of sheep Balantidium coli.The results showed that LC50,2 h of metronidazole,diminazene and oxytetracycline against trophozoite of sheep Balantidium coli were 0.213,0.418,0. 523 mg/mL, and LC50, 12 h were 0.056,0.107,0.149 mg/mL, respectively. It proved that metronidazole is one kind of highly effec- tive drug for killing trophozoite of sheep Balantidlum coLi in vitro.
作者
刘俊伟
周叶
宋开放
杨树宇
王文哲
姜金庆
LIU Jun-wei;ZHOU Ye;SONG Kai-fang;YANG Shu-yu;WANG Wen-zhe;JIANG Jin-qing(College of Animal Science and Veterinary Medicine,Henan lnstitute of Science and Technology,Xinxiang,Henan,453003,China)
出处
《动物医学进展》
北大核心
2018年第9期130-134,共5页
Progress In Veterinary Medicine
基金
2016年国家级大学生创新创业计划项目(201610467019)
2017年河南省教育厅重点科技攻关项目(17A230010)
2015年百农英才大学生创新项目(BNYC2015-2-08)
关键词
羊结肠小袋虫
滋养体
甲硝唑
半数致死浓度
sheep Balantidium coli
trophozoite
metronidazole
median lethal concentration
