摘要
感染性疾病病原诊断在抗菌药物合理应用,疾病流行病学监测和管理以及控制传播等方面发挥着核心作用.理想的感染病现场快速检验方法应具有敏感、快速、特异、稳定、低成本和便于使用的特点.本文概览了POCT在感染病抗原检测、抗体检测、核酸检测等方面的临床应用状况,并重点介绍了微流控技术在病原体多重核酸检测和耐药性检测等方面的优势和潜力.选择合适的时间、合适的场所、正确应用现场快速诊断技术,将为分级诊疗模式下的感染病诊治提供新的策略.
The pathogen diagnosis of infectious diseases plays a critical role in the rational application of antibiotics , the monitoring and management of disease epidemiology and the control of drug -resistant bacteria in hospitals and communities .The ideal method for rapid detection of infectious diseases should be sensitive, rapid, specific, stable, low-cost and easy to use.This article reviews the clinical application of POCT in infectious disease antigen detection , antibody detection , nucleic acid detection , etc. and focuses on the advantages and potential of microfluidic technology in pathogen multiplex nucleic acid detection and drug resistance detection .Choosing the right time , the right place , and the right on-site rapid diagnostic technology will provide a new strategy for the diagnosis and treatment of infectious diseases in the graded diagnosis and treatment mode .
作者
吴文娟
Wu Wenjuan(Medicine Laboratory,Tongji University East Hospital South Campus,Shanghai 200123,China)
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2018年第9期641-643,共3页
Chinese Journal of Laboratory Medicine
基金
国家自然科学基金（81472032）
上海市卫生系统优秀人才培养计划（2017BR032）
上海市浦东新区卫生系统重点学科（PWZxk201709）
关键词
感染性疾病
即时检验
微流体学
芯片分析技术
Infections diseases
Point-of-care testing
Microfluidics
Microchip analytical procedures
