摘要
目的:评价耳针压丸联合生脉胶囊治疗维持性血液透析(MHD)患者口渴及透析中低血压(IDH)的疗效。方法:本研究采用前瞻性、多中心、随机对照、交叉设计的研究方法。运用随机数字表法将来自北京中医药大学东直门医院、北京中医药大学东方医院和中国中医科学院望京医院、北京市第一中西医结合医院4家医院血液透析中心符合纳入标准的144例MHD患者随机分两组,在规律血液透析的基础上,两组均采用西医常规治疗方法,试验组加用耳针压丸联合生脉胶囊治疗,对照组只采用西医常规治疗方法。第一阶段治疗8周,结束后随访8周(含洗脱期),随访期间两组仅采用西医常规治疗方法。基于交叉试验原则,第一阶段随访结束后进行第二阶段的观察。评价两组间口渴程度和IDH的发生及对血液透析的影响。结果:试验组改善MHD患者口渴程度优于对照组(P<0.05);试验组在IDH的发生率、西医干预率、因低血压中断透析发生率和未完成超滤脱水量发生率方面优于对照组(P<0.05)。两组在sp KT/V和URR方面差异无统计学意义。结论:耳针压丸联合生脉胶囊方案可缓解MHD患者口渴症状,降低IDH的发生率,有助于减少因IDH导致的西医干预和中断血液透析次数,有利于完成目标超滤脱水量,治疗方法具有简便、安全的特点。
Objective： To observe the effects of Ear-acupoint pressing associated with Shengmai Capsule on relieving thirst and intradialytic hypotension in patients with hemodialysis. Methods： The prospective, multi-center, randomized controlled trial and crossover design were conducted. According to inclusion criteria, 144 patients who were from four centers included Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicin, Dongfang Hospital Affiliated to Beijing University of Chinese Medicin, Wangjing Hospital of CACMS, Beijing First Hospital of Integrated Chinese and Western Medicine with maintenance hemodialysis were randomly divided into two groups. Based on the regular hemodialysis, both group were adopted with western conventional treatment methods, the experimental group was treated with ear-acupoint pressing associated with Shengmai Capsule additional in the treatment stage, and The control group only used western medicine control methods. The first stage included 8 weeks of treatment, after the end, it had 8 weeks follow-up period（including washout period）, and two groups were adopted with conventional western medicine treatment only during the follow-up period. Based on the principle of cross-over trial, after the first phase of the follow-up, the second phase of the observation started. Evaluation the degree of thirsty, IDH occurrence and effects on hemodialysis. Results： The experimental group could relieve the degree of thirst of dialysis patients more than the control group（P〈0.05）. The experimental gropu was better than the control group as IDH occurrence rate, western medicine intervention rate, interrupted dialysis by intradialytic hypotension rate and the incidence of unfinished amount of ultrafiltration dehydration incidence rate（P〈0.05）. There were no differences in sp KT/V and URR between the two groups. Conclusion： Ear-acupoint pressing associated with Shengmai Capsule therapy relieves the degree of thirst of dialysis patients, reduces the IDH occurrence rate, bring down the times of western medicine intervention and interruption of hemodialysis and improves the amount of ultrafiltration dehydration target completion, with the characteristic of treatment is simple and safe.
作者
曹钋
刘福生
任可
钟剑
王玫
魏宇
张云凤
王欢
王薇薇
李春辉
王平
张蕊
刘锦
邱模炎
CAO Po;LIU Fu-sheng;REN Ke;ZHONG Jian;WANG Mei;WEI Yu;ZHANG Yun-feng;WANG Huan;WANG Wei-wei;LI Chun-hui;WANG Ping;ZHANG Rui;LIU Jinl;QIU Mo-tan(Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China;Dongfang Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100078,China;Beijing University of Chinese Medicine,Beijing 100029,China;Beijing First Hospital of Integrated Chinese and Western Medicine,Beijing 100026,China;Wanljing Honspital of CACMS,Beijing 100102,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2018年第9期4213-4216,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
北京中医药大学校级自主选题项目(No.2013-ZYLC-003
No.2017-JYB-JS-101)~~
关键词
耳针压丸
生脉胶囊
血液透析
口渴
透析中低血压
多中心随机对照研究
Ear-acupoint pressing
Shengmai Capsule
Hemodialysis
Thirst
Intradialytic hypotension
Multi-centerrandomized controlled trial
