摘要
目的:探讨血清白细胞介素-17(IL-17)、白细胞介素-23(IL-23)、免疫球蛋白E(Ig E)与慢性荨麻疹(CU)患者幽门螺杆菌(Hp)感染的相关性。方法:将108例CU患者根据检查结果分为Hp(+)CU组(66例)和Hp(-)CU组(42例),选取同期体检健康者60例作为健康对照组,比较各组间Hp阳性率及血清IL-17、IL-23、Ig E水平,并进行相关性分析。结果:CU组血清IL-17、IL-23、Ig E水平明显高于健康对照组(P值均<0.01),Hp阳性率(61.1%)亦明显高于健康对照组(31.7%)(P<0.05)。Hp(+)CU组血清IL-17、IL-23、Ig E水平明显高于Hp(-)CU组(P值均<0.01)。经Spearson相关性分析,血清中IL-17、IL-23、Ig E水平与CU患者Hp感染均呈正相关关系(P值均<0.05)。结论:Hp感染可引起慢性CU患者中血清IL-17、IL-23等细胞因子水平升高,从而导致机体免疫系统失衡,异常分泌Ig E,共同促进慢性荨麻疹的发生、发展。
Objective：To investigate the correlation of serum IL-17,IL-23,IgE with Helicobacter pylori（Hp） infection in patients with chronic urticaria（CU）.Methods：One hundred and eight patients with CU were selected from January 2016 to December 2017.According to the examination results,Hp（＋） CU group has 66 cases and Hp（-） CU group has 42 cases.60 healthy persons were selected as the healthy control group.The positive rate of Hp and the level of serum IL-17,IL-23,IgE were compared,and the correlation analysis was carried out.Results：The serum levels of IL-17,IL-23 and IgE were significantly higher in the CU group than that in the healthy control group（all P〈0.05）.The positive rate of Hp in CU group（61.1%） was significantly higher than that in the healthy control group（31.7%）（P〈0.05）.The serum levels of IL-17,IL-23,IgE in Hp（＋） CU group were significantly higher than those in Hp（-） CU group（all P〈0.01）.After Spearson correlation analysis,there was a positive correlation between the serum level of IL-17,IL-23,IgE and Hp infection of CU patients（all P〈0.05）.Conclusion：Hp infection can increase the level of cytokines such as IL-17,IL-23 and lead to the imbalance of immune system,increased production of IgE,and promote the occurrence and development of chronic urticaria.
作者
刘洋
姫雪冰
苏桂珍
LIU Yang;JI XUE-bing;SU Gui-zhen(Clinical Laboratory,Henan Zhongdu TCM Skin Diseases Hospital,Zhengzhou 450000,China)
出处
《皮肤性病诊疗学杂志》
2018年第4期200-203,共4页
Journal of Diagnosis and Therapy on Dermato-venereology
