摘要
目的:探讨DAPK蛋白、Ki-67蛋白在子宫内膜癌中的表达及其与临床病理学特征的相关性。方法:选取2012年6月至2016年10月在我院及邯郸市第一医院治疗的子宫内膜癌患者150例,同时选取150例子宫内膜增生患者,采用免疫组化法检测DAPK蛋白、Ki-67蛋白表达情况,采用全自动生化法检测血清中CEA、CA19-9和CA125等的表达,分析DAPK蛋白、Ki-67蛋白的表达与子宫内膜癌临床病理特征的关系。结果:子宫内膜癌患者组织中的DAPK蛋白低于子宫内膜增生组(P<0.05),Ki-67蛋白阳性表达率均高于子宫内膜增生组患者(P<0.05);子宫内膜癌组患者CEA、CA19-9和CA125水平均高于子宫内膜增生组(P<0.05);子宫内膜癌患者的DAPK阳性表达率与CEA等肿瘤标志物水平负相关(P<0.05),子宫内膜癌患者的Ki-67阳性表达率与CEA等肿瘤标志物水平正相关(P<0.05);不同年龄的患者间DAPK、Ki-67的表达无差异,高分化、无淋巴结转移、TNM分期为Ⅰ+Ⅱ期的子宫内膜癌患者的DAPK阳性表达率较高(P<0.05),高分化、无淋巴结转移、TNM分期为Ⅰ+Ⅱ期的子宫内膜癌患者的Ki-6 7阳性表达率较低(P<0.05)。结论:DAPK蛋白、Ki-67蛋白在子宫内膜癌患者中存在异常表达,且其表达与患者的病情或者细胞分化、淋巴结转移等具有密切关系。
Objective：To investigate the correlation between DAPK protein and Ki-67 protein in endometrial car-cinoma and its mechanism. Methods：From June 2012 to October 2016 with endometrial cancer patients in our hospi-tal treatment of 150 study, and 150 cases of endometrial hyperplasia patients （control group） were detected by immu-nohistochemistry, DAPK protein, Ki-67 protein, expression by automatic biochemical assay of serum CEA, CA19 - 9 and CA125 etc. The relationship between the expression of DAPK protein, Ki-67 protein and clinical pathological characteristics of endometrial carcinoma was analysed. Results ： Endometrial carcinoma tissue in DAPK protein was lower than that of control group （ P 〈 0.05 ）, the expression rate of Ki-67 was higher than that in the benign group （P 〈 0.05 ）. In endometrial cancer group, CEA, CA19-9 and CA125 were significantly higher than endometrial hy-perplasia group （ P 〈 0.05 ）. In endometrial carcinoma patients, the positive expression rates of DAPK were negatively with CEA tumor markers（ P 〈 0.05 ） , and the positive expression rates of Ki-67 were positively related to the level of tumor markers （ P 〈 0.05 ）. No expression difference occured in different age between patients with DAPK, Ki- 67. DAPK positive expression of high differentiation,non-lymph node metastasis,TNM stage Ⅰ ＋ Ⅱ of the uterus endo-metrial cancer was higher （P 〈 0.05 ）. Ki-67 positive expression of high differentiation, non -lymph node metasta-sis, TNM stage Ⅰ ＋ Ⅱ endometrial carcinoma rate was low （ P 〈 0.05 ）. Conclusion ： DAPK protein and Ki-67 pro-tein show abnormal expression in patients with endometrial cancer, and its expression was correlated with the patient＇s condition or cell differentiation, lymph node metastasis has a close relationship, have a potential value for the develop-ment of endometrial cancer.
作者
崔志利
安欣
刘巧珍
李静霞
刘文利
赵晶晶
毛希瑞
Cui Zhili;An Xin;Liu Qiaozhen;Li Jingxia;Liu Wenli;Zhao Jingjing;Mao Xirei(Hebei Engineering University Affiliated Hospital,Hebei Handan 056002,China;Hebei Handan City First Hospital,Hebei Handan 056000,China.)
出处
《现代肿瘤医学》
CAS
2018年第20期3289-3292,共4页
Journal of Modern Oncology
基金
邯郸市科学技术研究与发展计划项目(编号:1523108076-4)
