摘要
纳布啡是一种新型阿片受体激动-拮抗型镇痛药,主要激动κ受体,部分拮抗μ受体,在女性中较低剂量就可产生镇痛作用,被用于妇产科各类手术麻醉,如宫腔镜手术、妇科腹腔镜手术、妇科进腹手术、门诊日间手术和剖宫产手术等。较多研究表明,纳布啡可以提供良好的镇痛、镇静作用,患者苏醒时间短,循环系统稳定,不良反应少,哺乳产妇可以使用,还可促进泌乳,在妇产科麻醉中应用具有一定的优势,可在临床工作中根据具体情况选择使用。
Nalbuphine is a novel opioid receptor agonist-antagonist analgesic which primarily agonizes κreceptor and partially antagonizes μ receptor. It produces analgesic effects at lower doses in women and has been used in various surgical anesthesia of obstetrics and gynecology, such as hysteroscopic surgery, gynecological laparoscopic surgery, gynecological abdominal surgery, cesarean section, and so on. More studies have shown that nalbuphine can provide good analgesia and sedative effect, short recovery time, stable circulatory system,and patients have fewer adverse reactions. Nalbuphine can promote lactation and breast-feeding is permissible when it is administered to the mother. With certain advantages, nalbuphine can be selected in clinical work according to specific circumstances.
作者
鲍静影
杨云
BAO Jing-ying;YANG Yun(Department of Anesthesiology,Maanshan Municipal Health Hospital for Women and Children,Maanshan ANHUI 243001,China)
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2018年第8期439-442,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
纳布啡
妇产科
麻醉
nalbuphine
obstetrics and gynecology department
anesthesia
