摘要
脓毒症是严重创伤、大面积烧伤、感染和大手术等急危重患者的严重并发症,可诱发脓毒性休克和多器官功能障碍综合征（MODS）,其发病率和病死率一直居高不下.核转录因子-E2相关因子2（Nrf2）是抗氧化应激反应的重要转录因子,它通过调节抗氧化反应元件（ARE）介导的抗氧化酶和Ⅱ相解毒酶的表达,在脓毒症治疗中起关键作用.本文通过对Nrf2在脓毒症中的变化、相关调控机制及逆转措施进行综述,旨在为发掘脓毒症的有效干预措施提供参考.
Sepsis is a critical complication of severe trauma, large area burns, infection, and major surgery etc., which can induce septic shock and multiple organ dysfunction syndrome （MODS）, and its incidence and mortality are always high. Nuclear factor-E2 related factor 2 （Nrf 2） is an important transcription factor of antioxidant stress response. It plays a key role in the treatment of sepsis by regulating the expression of antioxidant enzyme and phase Ⅱ detoxification enzyme mediated by antioxidant response element （ARE）. In this article we review the changes, related regulation mechanism and reversing measures of Nrf 2 in sepsis, aiming to provide a reference for the effective intervention measures of sepsis.
作者
王星玉
陈涛
马晓媛
黄文娟
黄祺
刘宽
梁华平
Wang Xingyu;Chen Tao;Ma Xiaoyuan;Huang Wenjuan;Huang Qi;Liu Kuan;Liang Huaping(Department of Intensive Care Unit,the Affiliated Hospital of Zunyi Medical University,Zunyi 563003,Guizhou,Chin;State Key Laboratory of Trauma,Burns and Combined Injury,Research Institute of Surgery of the Third Affiliated Hospital,the Army Military Medical University,Chongqing 400042,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2018年第8期810-814,共5页
Chinese Critical Care Medicine
基金
国家自然科学基金（81671906）
