摘要
目的探讨来曲唑、苍附导痰汤联合治疗多囊卵巢综合征不孕患者的临床效果。方法选取我院2015年1月~2016年12月收治的多囊卵巢综合征患者248例,随机双盲法分为试验组和对照组,每组124例。对照组采用口服来曲唑治疗,试验组在对照组治疗基础上服用苍附导痰汤治疗。治疗后观察两组排卵、卵泡未破黄素化综合征(LUFS)和卵巢过度刺激综合征(OHSS)的发生情况,计算各组妊娠率。结果治疗后试验组排卵数、优势卵泡数分别为(6.23±1.79)个、(6.01±1.83)个,高于对照组的(4.25±0.71)个、(3.93±0.56)个,差异有统计学意义(P<0.05),随访1年后试验组妊娠率为36.29%,高于对照组的25.00%,差异有统计学意义(P<0.05);试验组LUFS、OHSS发生率分别为9.67%、0.81%,低于对照组的27.42%、4.84%,差异有统计学意义(P<0.05)。结论来曲唑联合苍附导痰汤能有效促进PCOS患者排卵,增加优势卵泡数,提高妊娠率。
Objective To investigate the clinical effects of letrozole and Cangfu Daotan decoction in the treatment of infertility patients with polycystic ovary syndrome.Methods A total of 248 patients with polycystic ovary syndrome admitted to our hospital from January 2015 to December 2016 were enrolled.The patients were randomly divided into the experimental group and the control group,with 124 patients in each group.The control group was treated with oral letrozole,and the experimental group was treated with Cangfu Daotan decoction on the basis of the control group.After treatment,the incidence of ovulation,follicular unbreaking luteinization syndrome（LUFS）and ovarian hyperstimulation syndrome（OHSS）were observed,and the pregnancy rate of each group was calculated.Results After treatment,the number of ovulation and the number of dominant follicles in the experimental group were（6.23±1.79）and（6.01±1.83）,which were higher than those in the control group（4.25±0.71）and（3.93±0.56）,the difference was statistically significant（P〈0.05）,the pregnancy rate of the experimental group was 36.29% after 1 year of follow-up,which was higher than that of the control group 25.00%,the difference was statistically significant（P〈0.05）.The incidence of LUFS and OHSS in the experimental group were 9.67% and 0.81 respectively lower than 27.42% and 4.84% of the control group,the difference was statistically significant（P〈0.05）. Conclusion Letrozole combined with Cangfu Daotan decoction can effectively promote ovulation in PCOS patients,increase the number of dominant follicles,and increase the pregnancy rate.
作者
李德君
李慧君
LI De-jun;LI Hui-jun(Department of Integrated Traditional Chinese and Western Medicine,Xinjiang Jiayin HospitaI,Urumqi 830001,Xinjiang,China;Maternal and Child Health Hospital of Xinjiang Autonomous Region,Urumqi 830001,Xinjiang,China)
出处
《医学信息》
2018年第17期137-139,142,共4页
Journal of Medical Information
关键词
来曲唑
苍附导痰汤
多囊卵巢综合征
不孕
促排卵
Letrozole
Cangfu Daotan decoction
Polycystic ovary syndrome
Infertility
Ovulation promoting
