摘要
目的:探究子宫肌瘤行米非司酮治疗的剂量选择与效果评估。方法:选取海南西部中心医院2013年5月至2016年5月收治的84例子宫肌瘤患者,将患者随机分成两组,每组42例,一组为观察组,采用小剂量治疗,每日服用12mg米非司酮。另一组为对照组,采用大剂量治疗,每日服用24mg米非司酮。观察两组患者的治疗效果。结果:观察组患者用药后的总有效率为90. 48%,对照组为85. 71%,观察组略优于对照组,两组数据差异无统计学意义(P> 0. 05)。观察组患者不良反应的发生率为9. 52%,明显低于对照组患者28. 57%,两组数据差异具有统计学意义(P <0. 05)。治疗前两组患者的各血清激素水平差异无统计学意义(P> 0. 05),治疗后都有下降,观察组明显对照组低,数据差异具有统计学意义(P <0. 05)。治疗前两组患者的肌瘤体积差异无统计学意义(P> 0. 05),治疗后肌瘤体积都有下降,观察组明显小于对照组,两组数据差异具有统计学意义(P <0. 05)。结论:子宫肌瘤患者采用低剂量米非司酮治疗有更好的效果,患者的不良反应能够有效降低,而且能够更好地缩小肌瘤体积,提高安全性,促进患者的治疗。
Objective：To study thedose selection and effect evaluation of mifepristone for treatment of uter ine leiomy-oma. Methods ：84 patients with uterine fibroids in Hainan West Central Hospital from May 2013 to May 2016were selected and randomly divided into two groups, each of 42 cases. The observation group was treated with 12 mg ketone, while the control group was given 24rag mifepristonedaily. The therapeutic effect of the two groups was observed. Results： The total effective rate was 90. 48% in the observation group and 85.71% in the control group, without statistically significant difference between the two groups （ P 〉 0. 05 ）. The incidence of adverse reactions in the observation group （9. 52% ） was significantly lower than that in the control group （28.57%）, with statistically significant difference between the two groups （ P 〈 0. 05 ）. There was no significant difference in serum hormone levels between the two groups before treatment （ P 〉 0. 05 ）, and the serum hormone levels of observationgroup were significantly lower than those of the control group after treatment （ P 〈 0. 05 ）. There was no significant difference in the volume of fibroids between the two groups before treatment （ P 〉 0. 05 ）. The volume of fibroids decreased after treatment in both groups and that of the observation group was significantly smaller than that of the control group, with statistically significant difference （P 〈 0. 05 ）. Conclusions：Low-dose mifepristone is of better effect for patients with uterine fibroids, whiehean effectively reduce incidence ofadverse reactions and the fibroid volume, improve safety and promote treatment effect.
作者
李华敏
林丽慧
林红满
王爱丽
LI Huamin;LIN Lihui;LIN Hongman;WANG Aili(Department of Pharmacy,Hainan West Central Hospital,Danzhou 571799,Hainan,China;Department of Obstetrics and Gynecology,Hainan West Central Hospital,Danzhou 571799,Hainan,China;Department of Obstetrics and Gynecology,Haikou Traditional Chinese Medicine Hospital,Haikou 570203,Hainan,China)
出处
《中国性科学》
2018年第8期65-67,共3页
Chinese Journal of Human Sexuality
基金
海南省医学科研课题项目(琼卫2013自筹-18)
关键词
子宫肌瘤
米非司酮
剂量选择
评估效果
Uterine fibroids
Mifepristone
Dose selection
Effectevaluation
