摘要
目的:分析孕晚期至产后1周妇女阴道解脲脲原体和人型支原体感染情况及抗生素敏感结果。方法:将宁波市第七医院300例孕晚期至产后1周的妇女作为研究对象,对其阴道分泌物进行支原体筛查及药敏试验,其中药敏试验的主要抗菌药有左氧氟沙星、环丙沙星、阿奇霉素、罗红霉素、司帕沙星、克拉霉素等。结果:300例患者中,检出支原体209例,感染率为69. 67%。其中,人型支原体单独感染9例(4. 31%),解脲脲原体单独感染149例(71. 29%),二者混合感染51例(24. 40%)。<20岁(9例)、21岁~25岁(81例)、26岁~30岁(71例)、31岁~35(38例)岁、> 35岁(10例)患者出现支原体感染。对于解脲脲原体,氟喹诺酮类药物耐药率显著高于大环内酯类和四环素类,差异具有统计学意义(P <0. 05);对于人型支原体和混合感染,氟喹诺酮类和大环内酯类药物耐药率显著高于四环素类,差异具有统计学意义(P <0. 05);人型支原体和混合感染患者四环素耐药率和大环内酯类耐药率显著高于解脲脲原体,差异具有统计学意义(P <0. 05);解脲脲原体、人型支原体和混合感染患者氟喹诺酮类耐药率差异无统计学意义(P>0. 05)。结论:孕晚期至产后1周的妇女生殖道支原体感染率较高,并且氟喹诺酮类等抗菌药物表现出较高的耐药性,而二代大环内酯类、四环素类抗菌药物的敏感性较高,同时对21岁~30岁的高危人群应积极进行临床干预。
Objective：To analyze the infection and antibiotic sensitivity of Ureaplasma urealyticum （Uu） and Mycoplasma hominis （Mh） in the late pregnancy to a week postpartum. Methods： 300 women in the late pregnancy to aweek postpartum were selected as the research objects. Mycoplasma screening and drug sensitivitywere detected, and the main antimicrobial agents used were levofloxacin, ciprofloxacin, azithromycin, roxithromycin, sparfloxacin, clarithromycin and so on. Results ： Among the 300 cases, Mycoplasma were detected in 209 cases, an infection rate of 69. 67% , whereMh infection was found in 9 cases （4.31%） , Uu infection was found in 149 cases （71.29%） , and mixed infection was found in 51 cases （24.40%）. There were 9 cases, 81 cases, 71 cases, 38 cases and 10 cases of mycoplasma infection in patients less than 20 years old, 21 -25 years old, 26 -30 years old, 31 -35 years old and 35 years old accordingly. For Uu, the resistance rate of fluoroquinolones was significantly higher than that of macrolides and tetracycline, with statistically significant difference （ P 〈 0. 05 ）. For Mh and mixed infection, the resistance rates of fluoroquinolones and macrolides were significantly higher than those of tetra- cycline, with statistically significant difference （ P 〈 0. 05 ）. The resistance rate of tetracycline and macrolide in pa- tients with Mh infection and mixed infection were higher than that of Uu （ P 〈 0. 05 ）. There is no statistical signifi- cance in the difference among patients with Mh infection, mixed infection and Uu infection regarding as fluoroquin- olone resistance rate （P 〉 0. 05）. Conclusions：The higher rate of late pregnancy and postpartum at 1 week of infec- tion in women genital tract mycoplasma, and fluoroquinolones and other antimicrobial agents show high resistance, and the twice generation macrolides, tetracycline antibiotic sensitive drugs, at the same time on the high risk population aged 21 -30 years old should actively carry- out clinical intervention.
作者
许丹丹
凌艳姣
XU Dandan;LING Yanjiao(Department of Obstetrics,Ningbo Seventh Hospital,Ningbo 315202,Zhejiang,China)
出处
《中国性科学》
2018年第8期107-109,共3页
Chinese Journal of Human Sexuality
关键词
孕产妇
解脲脲原体
人型支原体
抗生素
Pregnant and lying in women
Ureaplasma urealyticum （Uu）
Mycoplasma hominis （Mh）
Antibiotics
