摘要
外泌体是一种具有双层膜结构的囊泡样小体,包含丰富的蛋白质、核酸尤其是微小RNA(microRNA,miR)。miR是内源性单链非编码RNA,参与基因转录和转录后翻译,调节基因表达。miR可通过外泌体从供体细胞转运至受体细胞,是细胞间信息交流的新方式,在心血管疾病的发生、发展中发挥重要作用。本文就外泌体miR在心血管疾病发生、发展中作用的研究进展作一综述。
Exosomes are vesicle like bodies with a double-layered membrane structure, containing abundant proteins and nucleic acids, especially microRNAs. MicroRNAs are endogenous, single-stranded and non-coding RNAs that are involved in the transcription and post-transcriptional regulation of genes. MicroRNAs have been demonstrated a new way of communication among cells by effectively delivering to a target cell from a host cell via exosomes, playing an impotrant role in the development and progression of cardiovascular diseases. This paper reviews the research progress of the role of exosomal microRNAs in the development and progression of cardiovascular diseases.
作者
刘中
产进中
张野
何淑芳
LIU Zhong;CHAN Jinzhong;ZHANG Ye;HE Shufang(Department of Anesthesiology,the Second Hospital of Anhui Medical University,Hef ei 230601,China)
出处
《中华实用诊断与治疗杂志》
2018年第9期934-936,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
安徽省高等学校自然科学研究项目重点项目(KJ2017A172)
