摘要
目的探讨氟西汀对急性脑梗死患者运动功能恢复及认知功能改善的作用。方法选取2016年1~12月,唐山市人民医院收治的急性脑梗死患者75例,随机分为观察组与对照组,观察组40例,在神经内科常规治疗基础上予口服氟西汀;对照组35例,予神经内科常规治疗。分别在治疗前,治疗后第2、4、8周进行美国国立卫生研究院卒中量表(NIHSS)评分、蒙特利尔认知评估(MoCA)量表评分。结果治疗后第4、8周,两组NIHSS评分差异有统计学意义(t=4.225、6.364,P=0.048、0.016)。治疗后第8周,两组患者MoCA评分差异有统计学意义(t=38.732,P=0.000)。随着氟西汀治疗时间的延长,观察组患者NIHSS评分下降(F=6.229,P=0.001),MoCA评分升高(F=27.404,P=0.000),差异均有统计学意义。结论氟西汀能改善急性脑梗死患者运动与认知功能,对于提高患者生存质量具有重要意义。
Objective To explore the effect of fluoxetine on mobile and cognitive function recovery of patients with acute cerebral infarction. Methods 75 patients with acute cerebral infarction admitted to The People′s Hospital of Tangshan from January to December 2016 were recruited and randomly divided into observation group（n= 40）and control group（n=35）.Patients in observation group were treated with fluoxetine besides basic neurological care,while patients in control group only received basic treatment.The National Institutes of Health Stroke Scale（NIHSS）score and the Montreal cognitive assessment（MoCA）scale score were administered before treatment as well as 2 weeks,4 weeks and 8 weeks after treatment. Results At week 4 and 8 of fluoxetine treatment,the difference in NIHSS score between the two groups was statistically significant（t=4.225,6.364,P=0.048,0.016）.At week 8 of treatment,the difference in MoCA score between the two groups was statistically significant（t=38.732,P=0.000）.The NIHSS score decreased（F=6.229,P=0.001）while the MoCA score increased（F=27.404,P=0.000）along with fluoxetine treatment and the differences were statistically significant. Conclusions Fluoxetine treatment improves the recovery of neurological function in patients with acute cerebral infarction.
作者
王彦
穆珊珊
王洋
张凤莲
李艳琴
WANG Yan;MU Shan-shan;WANG Yang;ZHANG Feng-lian;LI Yan-qin(The People＇s Hospital of Tangshan,Tangshan,Hebei 063001,China)
出处
《中国预防医学杂志》
CAS
CSCD
2018年第8期597-599,共3页
Chinese Preventive Medicine
基金
河北省卫生厅科研立项项目(20120460)
关键词
氟西汀
急性脑梗死
运动功能
认知功能
Fluoxetine
Acute cerebral infarction
Mobile function
Cognitive function
