摘要
目的:利用中医传承辅助平台(V2.5)分析傅晓骏教授治疗早中期慢性肾功能衰竭的临床用药规律。方法:建立治疗早中期慢性肾功能衰竭所拟处方数据库,运用软件中的多种数据挖掘方法对594张处方中的用药规律进行统计和分析。结果:药物使用频次达50次以上的有53味中药,所用药物的四气以温、平、寒为主,共占比92%;五味以甘、苦、辛为主,共占比93%;归经以脾、肝、肾为主,共占比51%,其次为肺、胃、心,共占比34%。黄芪、白术、淫羊藿、丹参、大黄、陈皮、土茯苓、黄精、桃仁、积雪草、茯苓、川芎、沉香、太子参、仙茅是核心药物群。熵层次聚类分析共得出3个新组合,分别是:六月雪、莪术、石见穿、核桃仁;黄精、大黄、淫羊藿、桑寄生、牛膝、杜仲、细辛;猪苓、桑白皮、茯苓皮、大腹皮、茯苓、泽泻、山药、牡丹皮。结论:使用中医传承辅助平台(V2.5)分析傅教授治疗早中期慢性肾功能衰竭的用药规律,其分析结果不仅可以全面、客观地总结名老中医们的用药规律,还可用于指导年轻医生的临床诊疗。
Objective：To analyze the clinical administration rules in the treatment of chronic renal failure（CRF） in early and middle stages by FU Xiaojun based on Chinese medicine inheritance platform system（V2.5）. Methods：Established a database of prescription for CRF in the early and middle stages,and used various data mining methods in the software to conduct statistics and analysis on the administration rules in 594 prescriptions. Results：There were 53 kinds of Chinese herbal medicines that had been used more than 50 times. In terms of the four natures of Chinese herbal medicines,those used were mainly warm,neutral and cold（92%）. In terms of the five flavors,those mainly were sweet,bitter and acrid（93%）. In terms of the channel entry,those associated with the spleen,liver and kidney were majority（51%）,followed by those associated with the lung,stomach and heart（34%）. The core Chinese herbal medicine group included Radix Astragali, Rhizoma Atractylodis Macrocephalae, Herba Epimedii, Radix et Rhizoma Salviae Miltiorrhizae,Radix et Rhizoma Rhei, Pericarpium Citri Reticulatae, Rhizoma Smilacis Glabrae, Rhizoma Polygonati, Semen Persicae, Herba Centellae,Poria,Rhizoma Chuanxiong,Lignum Aquilariae Resinatum,Radix Pseudostellariae and Rhizoma Curculiginis. Three new combinations were obtained by the entropy cluster analysis：（1）Herba Serissae, Rhizoma Curcumae, Herba Salviae Chinensis and Semen Juglandis;（2）Rhizoma Polygonati, Radix et Rhizoma Rhei, Herba Epimedii, Herba Taxilli, Radix Achyranthis Bidentatae,Cortex Eucommiae and Radix et Rhizoma Asari;（3）Polyporus, Cortex Mori, Cutis Poriae, Pericarpium Arecae, Poria, Rhizoma Alismatis, Rhizoma Dioscoreae and Cortex Moutan. Conclusion： This research uses the software of Chinese medicine inheritance platform system to analyze the administration rules of Professor Fu＇s prescription for CRF in the early and middle stages,whose analysis result not only can comprehensively and objectively summarize the administration rules of experienced practitioners, but can also be used to guide the young practitioners in clinical diagnosis and treatment.
作者
钱璐
李伟明
傅晓骏
QIAN Lu;LI Weiming;FU Xiaojun
出处
《新中医》
CAS
2018年第9期116-120,共5页
New Chinese Medicine
基金
金华市科学技术局社会发展类一般项目(2016-4-020)
关键词
中医传承辅助平台(V2.5)
傅晓骏
慢性肾功能衰竭
用药经验
Chinese medicine inheritance platform system （V2.5）
FU Xiaojun
Chronic renal failure
Administration rule
