摘要
目的观察99Tc－亚甲基二膦酸盐（商品名：云克）联合钙剂和维生素D3对类风湿关节炎（RA）及RA骨质疏松的治疗效果。方法选取2015年1月至2016年12月间的50例RA骨质疏松患者作为观察组，其中男19例、女31例，平均年龄（56.21±18.32）岁，给予云克、钙剂和维生素D3治疗。选取39例RA骨质疏松患者作为对照组，给予甲氨蝶呤、钙剂和维生素D3治疗，其中男16例、女23例，平均年龄（60.37±12.56）岁。比较治疗前与治疗后（3、6、12个月） 2组患者RA症状及骨密度（BMD）改善情况等。采用两样本t检验分析数据。结果2组患者在治疗后3和6个月在改善晨僵、减少关节压痛及肿胀方面均有较好治疗效果，两者疗效差异无统计学意义（t值：0.3～0.6，均P〉0.05）。治疗后6个月，观察组患者L2～L4椎体与股骨颈BMD分别为（0.64±0.05）和（0.59±0.06） g/cm2，治疗后12个月分别为（0.81±0.04）和（0.79±0.06） g/cm2，均高于同期对照组相应BMD[（0.51±0.04）和（0.50±0.05）、（0.59±0.03）和（0.52±0.05） g/cm2；t值：8.3～9.9，均P〈0.05]。结论云克联合钙剂和维生素D3对RA引起的骨质疏松治疗效果明显。
ObjectiveTo observe the efficacy of 99Tc-methylene diphosphonate （MDP） combined with calcium and vitamin D3 in the treatment of rheumatoid arthritis （RA） and secondary osteoporosis.MethodsFifty patients （19 males, 31 females, average age： （56.21±18.32） years） with RA and secondary osteoporosis from January 2015 to December 2016 were selected as observation group. All of them were treated with 99Tc-MDP, calcium and vitamin D3. Another 39 patients with RA and secondary osteoporosis were randomly selected as control group, including 16 males and 23 females （average age： （60.37±12.56） years）, and all were treated with methotrexate, calcium and vitamin D3. Curative effects before and after （3, 6, 12 months） the treatment were observed and compared. Two-sample t test was used for data analysis.ResultsBoth of the 2 groups showed good response, and there was no statistical significance in improvement of morning stiffness, reducing joint tenderness and swelling （t values： 0.3-0.6, all P〉0.05）. The bone mineral density （BMD） of L2-L4 vertebral bodies and femoral neck were （0.64±0.05） and （0.59±0.06） g/cm2 6 months after treatment, and were （0.81±0.04） and （0.79±0.06） g/cm2 12 months after treatment in the observation group, which were all higher than those in the control group （（0.51±0.04）, （0.50±0.05）, （0.59±0.03）, （0.52±0.05） g/cm2;t values： 8.3-9.9, all P〈0.05）.Conclusion99Tc-MDP combined with calcium and vitamin D3 for RA and RA osteoporosis may achieve good curative effect.
作者
黄禾
陈跃
Huang He;Chert Yue(Department of Nuclear Medicine,the Affiliated Hospital of Southwest Medical University,Luzhou 646000,China)
出处
《中华核医学与分子影像杂志》
CAS
北大核心
2018年第9期615-618,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
关键词
关节炎
类风湿
骨质疏松
胆骨化醇
99M锝美罗酸盐
治疗结果
Arthritis
rheumatoid
Osteoporosis
Cholecalciferol
Technetium Tc 99m medronate
Treatment outcome
