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硝苯地平与培哚普利吲达帕胺联合美托洛尔治疗顽固性高血压临床研究 被引量:4

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摘要 目的:探讨硝苯地平与培哚普利吲达帕胺联合美托洛尔治疗顽固性高血压的临床疗效。方法:选取84例顽固性高血压患者,随机分为观察组与对照组,各42例。对照组给予硝苯地平+培哚普利吲达帕胺治疗,观察组在此基础上联合美托洛尔治疗,两组均治疗2个月。对比两组治疗前后心率(HR)、血压[收缩压(SBP)、舒张压(DBP)]、生活质量(SF-36评分)及治疗期间不良反应发生率。结果:治疗前、后两组HR较治疗前差异无统计学意义(P>0.05);治疗后两组SBP、DBP较治疗前降低,差异有统计学意义(P<0.05),且观察组SBP、DBP低于对照组,差异有统计学意义(P<0.05);治疗后两组SF-36评分较治疗前增加,差异有统计学意义(P<0.05),且观察组SF-36评分高于对照组,差异有统计学意义(P<0.05);观察组头晕/头痛、发热感、便秘、疲劳等发生率与对照组比较差异无统计学意义(P>0.05)。结论:硝苯地平与培哚普利吲达帕胺联合美托洛尔治疗顽固性高血压疗效明显,可有效降低血压水平,且具有一定安全性,对患者心率无明显影响,有利于改善患者生活质量。
作者 吴玉强
出处 《山西职工医学院学报》 CAS 2018年第4期34-36,共3页 Journal of Shanxi Medical College for Continuing Education
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  • 1房晓芳,范克新,肖庆飞,杨立志.顽固性高血压与慢性肾脏病[J].中国老年学杂志,2014,34(8):2303-2305. 被引量:3
  • 2Arun Kannan,Raul Ivan Medina,Nagapradeep Nagajothi,Saravanan Balamuthusamy.Renal sympathetic nervous system and the effects of denervation on renal arteries[J].World Journal of Cardiology,2014,6(8):814-823. 被引量:9
  • 3鲁永菊,周蜜.复方丹参滴丸治疗顽固性高血压[J].中西医结合心脑血管病杂志,2007,5(4):291-292. 被引量:11
  • 4郑琼莉,祝炜,王超,贾晶,毛莉娜,李红兵.顽固性高血压病人中医证型及血压形态特点分析[J].中西医结合心脑血管病杂志,2007,5(3):193-194. 被引量:23
  • 5Calhoun DA,Jones D, Textor S, et al. Resistant hypertension:diagnosis, evaluation, and treatment. A scientific statement fromthe American Heart Association Professional Education Committeeof the Council for High Blood Pressure Research. Hypertension,2008, 51:1403-1419.
  • 6Chobanian AV, Bakris GL, Black HR, et al. Joint NationalCommittee on Prevention,Detection,Evaluation, and Treatmentof High Blood Pressure. National Heart, Lung, and BloodInstitute; National Heart, Lung, and Blood Institute; NationalHigh Blood Pressure Education Program Coordinating Committee.Seventh report of the Joint National Committee on prevention,detection, evaluation, and treatment of high blood pressure.Hypertension, 2003,42 : 1206-1252.
  • 7Dahlof B,Sever PS, Poulter NR, et al. ASCOT Investigators.Prevention of cardiovascular events with an antihypertensiveregimen of amlodipine adding perindopril as required versusatenolol adding bendroflumethiazide as required, in the AngloScandinavian Cardiac Outcomes Trial-Blood Pressure LoweringArm ( ASCOT-BPLA) : a multicentre randomised controlled trial.Lancet,2005,366 : 895 -906.
  • 8Jamerson K,Weber MA, Bakris GL, et al. ACCOMPLISH TrialInvestigators. Benazepril plus amlodipine or hydrochlorothiazidefor hypertension in high-risk patients. N Engl J Med,2008,359:2417-2428.
  • 9Schmieder RE,Redon J, Grassi G,et al. ESH position paper:renal denervation - an interventional therapy of resistanthypertension. J Hypertens, 2012, 30:837-841.
  • 10Tsioufis C, Kordalis A, Flessas D, et al. Pathophysiology ofresistant hypertension : the role of sympathetic nervous system.Int J Hypertens, 2011,ID :642416.

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