摘要
目的分析研究不同剂量米非司酮治疗子宫肌瘤的临床效果。方法 2016年9月—2018年1月期间,方便选择到该院就诊的88例子宫肌瘤患者,采取数字抓阄的方式进行分组,单号设为对照组(n=44),双号设为实验组(n=44)。对照组,25 mg/d米非司酮治疗,实验组,12.5 mg/d米非司酮治疗,观察临床疗效。结果数据显示,实验组总有效率为88.6%,对照组为84.1%,差异有统计学意义(χ~2=0.859,P=0.354)。比较临床指标,治疗前与治疗后组间差异无统计学意义(P>0.05)。统计不良反应,实验组发生率为6.8%,对照组为15.9%,差异有统计学意义(χ~2=4.115,P=0.042)。结论米非司酮治疗子宫肌瘤,效果显著,相比高剂量,低剂量用药,不良反应少,更安全。
Objective To analyze the clinical effects of different doses of mifepristone in the treatment of uterine fibroids.Methods From September 2016 to January 2018, 88 patients with uterine leiomyoma who were convenient selected fortreatment in the hospital were divided into groups by digital grabbing. The single number was set as the control group（n=44）and experimental group （n=44） with 25 mg/d mifepristone treatment and 12.5 mg/d mifepristone treatment, observe the clinical efficacy. Results The data showed that the total effective rate was 88.6% in the experimental group and 84.1% in thecontrol group,the difference was statistically significnat（X^2=0.859, P=0.354）. Compared with clinical indicators, there was nosignificant difference between pre-treatment and post-treatment groups（P〉0.05）. The statistical analysis of adverse reactionsoccurred in 6.8% in the experimental group and 15.9% in the control group,the difference was statistically significnat（X^2=4.115, P=0.042）. Conclusion Mifepristone is effective in the treatment of uterine fibroids. Compared with high-dose andlow-dose drugs, the adverse reactions are less and safer.
作者
刘亚丽
LIU Ya-li(No.208 Hospital of Chinese People＇s Liberation Army,Changchun,Jilin Province,130062 China)
出处
《中外医疗》
2018年第24期123-124,127,共3页
China & Foreign Medical Treatment
关键词
剂量
米非司酮
子宫肌瘤
治疗效果
Dose
Mifepristone
Uterine fibroids
Therapeutic effect
