摘要
目的探究转移抑制基因nm23-H1在结肠癌患者组织中的表达及其临床意义。方法回顾性分析154例结肠黏膜病变患者临床资料,根据其病理检查结果分为观察组(结肠癌,n=68)与对照组(结肠息肉,n=86)。采集两组患者病灶组织标本后进行免疫组织化学法(IHC)检测,分析两组nm23-H1蛋白表达差异及其与肿瘤淋巴转移、远处器官转移、Duke’s大肠癌分期的相关性。结果观察组病灶标本nm23-H1蛋白表达阳性率明显低于对照组(P<0.05),且其中有淋巴结转移亚组<无淋巴结转移亚组<对照组,有远处器官转移亚组<无远处器官转移亚组<对照组,组间差异均有统计学意义(P<0.05)。经Spearman相关性分析,可知结肠癌淋巴结转移、远处器官转移与其组织nm23-H1蛋白表达呈显著负相关(P<0.05)。结论结肠癌组织中nm23-H1蛋白表达阳性率较低,且与其转移潜力相关性良好,可为患者预后评估提供可靠依据。
Objective To investigate the expression and clinical significance of metastasis suppressor gene nm23-H1 in patients＇ tissues of colon cancer. Methods The clinical data of 154 patients with colonic mucosal lesions was retrospectively analyzed.According to the pathological examination results,the patients were divided into the observation group（ colon cancer,n = 68） and control group（ colon polyp,n = 86）. The tissue samples of the two groups were collected and detected with immunohistochemical（ IHC） methods. The difference of nm23-H1 protein expressions and the correlations with tumor lymphatic metastasis,distant organ metastasis and Duke＇s colorectal cancer staging were analyzed in the two groups.Results The positive expression rate of nm23-H1 protein in the observation group was significantly lower than that of the control group（ P〈0.05）,and it was the highest in the control group,followed by the non lymph node metastasis subgroup and lymph node metastasis subgroup. The case was the same with control group,non distant organ metastasis subgroup and distant organ metastasis subgroup（ P〈0.05）. According to Spearman correlation analysis,lymph node metastasis and distant organ metastasis of colon cancer were significantly negatively correlated with the expression of nm23-H1 protein（ P〈0.05）. Conclusion The positive rate of metastasis suppressor gene nm23-H1 is not only low in colon cancer tissues,but has a good correlation with metastatic potential,thus facilitating the postoperative adjuvant therapy and prediction of prognosis.
作者
初桂伟
王利伟
赵月
田春燕
李馥郁
苏楠
王连友
CHU Guiwei;WANG Liwei;ZHAO Yue;TIAN Chunyan;LI Fuyu;SU Nan;WANG Lianyou(Department of Medical Oncology, the Fourth Hospital of Qinhuangdao, Qinhuangdao Hebei 066000, China)
出处
《解放军预防医学杂志》
CAS
2018年第9期1185-1187,1210,共4页
Journal of Preventive Medicine of Chinese People's Liberation Army
基金
秦皇岛市科学技术研究与发展计划项目(No.201401A114)
