摘要
IL-33是IL-1家族成员,早期研究发现其主要在Ⅱ型免疫反应中发挥作用,近年来大量研究报道IL-33在肿瘤免疫反应中也发挥了重要的调节作用。但是,不同研究中IL-33对于肿瘤进展的作用及其机制仍然存在争议。通过对已有报道的整理,发现IL-33的作用与肿瘤起源组织类型、发展阶段和肿瘤微环境相关,提示IL-33的作用具有组织或区域特异性。充分分析和揭示IL-33在不同环境中的作用,是其应用于临床诊断及治疗的前提。
Interleukin-33 （IL-33）, as interleukin-1 like cytokine, plays important roles in type Ⅱ immune responses. Recent studies suggest that IL-33 involves in tumor progression through modulating immune response, but the roles and mechanism are still controversial. These diverse results are likely due to the tissue origin, stage and microenvironment of the tumor, which implicates that IL-33 acts multiple roles in a context-dependent manner. To reveal the distinct roles of IL-33 in tumor development, further studies should be performed in more refined conditions. The profound understanding of IL-33 function in tumor progression is necessary for its application in clinical diagnosis and treatment.
作者
亓璐
苗玉辉
肖卫华
方芳
QI Lu;MIAO Yu-hui;XIAO Wei-hua;FANG Fang(Institute of Immunology,School of Life Sciences,University of Science and Technology of China,Hefei 23002;The CAS Key Laboratory of Innate Immunity and Chronic Disease,Hefei 230027;Hefei National Laboratory for Physical Sciences at the Microscale,Hefei 230027,China)
出处
《生物学杂志》
CAS
CSCD
北大核心
2018年第5期1-7,共7页
Journal of Biology
基金
国家重点基础研究发展计划(973计划)资助项目(编号：2016YFC1303503)
安徽省科技厅重大专项资助项目(编号：17030801024)
