摘要
目的分析布地奈德混悬液和硫酸沙丁胺醇溶液联合吸入对慢性阻塞性肺疾病患者的临床治疗效果。方法将2015年1月～2017年6月期间收治的80例慢性阻塞性肺疾病患者作为研究对象,根据随机数字表分为三组。A组(n=25)患者给予吸入用布地奈德混悬液治疗, B组(n=25)患者给予吸入用硫酸沙丁胺醇溶液治疗; C组(n=30)患者给予联合药物治疗,观察对比三组患者的临床治疗效果、临床症状及不良反应情况。结果 (1) A组患者总有效率为68.00%,B组患者总有效率为68.00%,C组患者总有效率为96.67%,C组治疗总有效率明显高于A组、B组,组间差异均具统计学意义(P <0.05),A组与B组间未见明显差异。(2) C组患者的体温恢复时间是(2.0±0.1)d,呼吸困难时间是(4.1±1.1)d,肺部啰音消失的消失时间是(3.1±0.4)d,咳嗽咳痰时间是(6.9±0.2)d;各项指标均低于A、B两组;(3) A组不良反应的发生率是28%,B组的是24%,C组的是6.67%,联合用药的C组不良反应发生率明显低于A组、B组(P <0.05)。结论和布地奈德混悬液或硫酸沙丁胺醇溶液单独应用的情况相比,布地奈德和沙丁胺醇联合雾化吸入治疗可以显著提高慢性阻塞性肺疾病患者的临床治疗效果及临床症状,且其不良反应的发生率较低。
Objective To analyze the clinical effect of combined inhalation of budesonide suspension and salbutamol sulfate on patients with chronic obstructive pulmonary disease. Methods The subjects of this study were 80 patients with chronic obstructive pulmonary disease in the hospital. The treatment time was from January 2015 to June 2017. All the above patients were diagnosed and divided into 3 groups. Patients in group A were only inhaled with budesonide suspension, and patients in group B were given only inhalation of salbutamol sulfate; patients in group C were inhaled with budesonide suspension and salbutamol sulfate, then to observe the clinical effects of the three groups of patients. Treatment effects, clinical symptoms and adverse reactions were compared. Results In group A, The total effective rate was 68.00%, 68.00% in group B, 96.67% in group C. C group of patients＇ temperature recovery time was （ 2.0± 0.1 ） d, dyspnea time was （4.1 ± 1.1 ） d, Disappearance time of pulmonary tales disappear was （3.1 ± 0.4） d, cough cough time was （ 6.9 ± 0.2） d; all indicators were lower than A and B groups; the incidence of adverse reactions in 3 group, A was 28%, 24% in group B, and 6.66% in group C. he treatment effect of group C was significantly better than that of group A and group B, and the difference was statistically significant （P 〈 0.05）. Conclusion Compared with budesonide suspension or salbutamol sulfate alone, the combination of budesonide and salbutamol inhalation therapy can significantly improve the clinical efficacy and clinical symptoms of patients with chronic obstructive pulmonary disease, and its incidence of adverse reactions is low , which is worthy of widespread clinical promotion.
作者
曹丽丽
CHAO Li-li(Lianshui County People＇s Hospital,Pharmacy Department,Huaian Jiangsu 223400,China)
出处
《中国处方药》
2018年第10期86-87,共2页
Journal of China Prescription Drug
关键词
布地奈德混悬液
硫酸沙丁胺醇
吸入治疗
慢性阻塞性肺疾病
Budesonide suspension
Salbutamol sulfate
Combination
Inhalation therapy
Chronic obstructive pulmonary disease
